Rachael T. Richardson

TL;DR: Four new SOCS proteins (SOCS-4 to SOCS-7) containing an SH2 domain and a SOCS box are described, and three new families of proteins that contain either WD-40 repeats (WSB-1 and -2), SPRY domains (SSB-1 to -3) or ankyrin repeats (ASB-3) N-terminal of the SOCSbox are described.

TL;DR: It appears that the SOCS proteins may act as adaptor molecules that target activated cell signaling proteins to the protein degradation pathway, analogous to the family of F-box-containing proteins.

TL;DR: Guinea pigs implanted with electrically stimulated Ppy/pTS/NT3-coated electrodes had lower electrically-evoked auditory brainstem response thresholds and greater SGN densities in implanted cochleae compared to non-implanted cochlearae and compared to animals implanted with Ppy-pTS-coating electrodes (p<0.05).

TL;DR: If applied to the cochlear implant, Ppy/pTS/NT3 will provide a biocompatible, low-impedance substrate for storage and release of NT3 to help protect auditory neurons from degradation after sensorineural hearing loss and encourage neurite outgrowth towards the electrodes.

TL;DR: Examination of the morphological effects on auditory neurons following deafening and the administration of brain‐derived neurotrophic factor and neurotrophin‐3 showed that neurotrophins were effective in preventing death of auditory neurons if administered 5 days after deafening or in preventing the continued loss of neurons if the administration was delayed by 33 days.