S
Stephen Van Komen
Researcher at Yale University
Publications - 24
Citations - 3569
Stephen Van Komen is an academic researcher from Yale University. The author has contributed to research in topics: DNA repair & Replication protein A. The author has an hindex of 23, co-authored 23 publications receiving 3436 citations. Previous affiliations of Stephen Van Komen include University of Texas Health Science Center at San Antonio.
Papers
More filters
Journal ArticleDOI
DNA helicase Srs2 disrupts the Rad51 presynaptic filament
Lumir Krejci,Stephen Van Komen,Ying Li,Jana Villemain,Mothe Sreedhar Reddy,Hannah L. Klein,Thomas E. Ellenberger,Patrick Sung +7 more
TL;DR: The role of SRS2 in recombination modulation is clarified by purifying its encoded product and examining its interactions with the Rad51 recombinase, and it is shown that Srs2 acts by dislodging Rad51 from ssDNA.
Journal ArticleDOI
Rad51 Recombinase and Recombination Mediators
TL;DR: Homologous DNA pairing and strand exchange reaction is mediated by a class of conserved recombinase enzymes: UvsX in bacteriophage T4, RecA in Escherichia coli, and Rad51 in eukaryotes (11, 12).
Journal ArticleDOI
Mediator function of the human Rad51B–Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange
TL;DR: Five Rad51-like proteins, referred to as Rad51 paralogs, have been described in vertebrates and it is shown that two of them, Rad51B and Rad51C, are associated in a stable complex that has ssDNA binding and ssDNA-stimulated ATPase activities.
Journal ArticleDOI
Superhelicity-driven homologous DNA pairing by yeast recombination factors Rad51 and Rad54.
TL;DR: A specific interaction of Rad54 with the Rad51-ssDNA complex enhances the ability of the former to remodel DNA and allows the latter to harvest the negative supercoils generated for DNA joint formation.
Journal ArticleDOI
Recruitment of the Recombinational Repair Machinery to a DNA Double-Strand Break in Yeast.
TL;DR: ChIP time courses from various mutant strains and additional biochemical studies suggest that Rad52p, Rad55p, and Rad54p each help promote the formation and/or stabilization of the Rad51p nucleoprotein filament and all four Rad proteins associate with homologous donor sequences during strand invasion.