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Stephen W. Byers
Researcher at Georgetown University
Publications - 67
Citations - 4867
Stephen W. Byers is an academic researcher from Georgetown University. The author has contributed to research in topics: Wnt signaling pathway & Cancer. The author has an hindex of 31, co-authored 67 publications receiving 4645 citations. Previous affiliations of Stephen W. Byers include Georgetown University Medical Center & Yeshiva University.
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Journal ArticleDOI
Extracellular matrix regulates Sertoli cell differentiation, testicular cord formation, and germ cell development in vitro.
TL;DR: Sertoli cells cultured on top of extracellular matrix components assume a phenotype and morphology more characteristic of the in vivo, differentiated cells, which induces a morphogenesis of the cells into cords, which closely resemble the organ from which the cells were dissociated and which provide an environment permissive for germ cell differentiation.
Journal Article
β-Catenin Affects Androgen Receptor Transcriptional Activity and Ligand Specificity
TL;DR: Findings implicate beta-Catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer.
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Liver stem cells and hepatocellular carcinoma
Lopa Mishra,Tanuj Banker,Joseph C. Murray,Stephen W. Byers,Arun Thenappan,Aiwu Ruth He,Kirti Shetty,Lynt B. Johnson,E P Reddy +8 more
TL;DR: A rationale for detecting and analyzing tumor stem cells as one of the most effective ways to treat cancers such as HCC is provided.
Journal ArticleDOI
Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest.
TL;DR: It is demonstrated that modest overexpression of β-catenin in a normal epithelial cell results in cellular transformation and functions as an oncogene by promoting the G1 to S phase transition and protecting cells from suspension-induced apoptosis (anoikis).
Journal Article
Cadherin-11 Is Expressed in Invasive Breast Cancer Cell Lines
Michael J. Pishvaian,Carolyn M. Feltes,Patrick Thompson,Marion J.G. Bussemakers,Jack A. Schalken,Stephen W. Byers +5 more
TL;DR: Results suggest that cadherin-11 expression may be well correlated with the invasive phenotype in cancer cells and may serve as a molecular marker for the more aggressive, invasive subset of tumors.