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Stephen W. Fesik
Researcher at Vanderbilt University
Publications - 298
Citations - 42613
Stephen W. Fesik is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Binding site. The author has an hindex of 95, co-authored 294 publications receiving 40006 citations. Previous affiliations of Stephen W. Fesik include Howard Hughes Medical Institute & Yale University.
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Journal ArticleDOI
Heteronuclear three-dimensional NMR spectroscopy. Natural abundance carbon-13 chemical shift editing of 1H-1H COSY spectra
TL;DR: In this paper, it has been demonstrated that heteronuclear 3D NMR spectroscopy can be effectively applied to small molecules with {sup 13}C at natural abundance.
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Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.
Taekyu Lee,Plamen P. Christov,Subrata Shaw,James C. Tarr,Bin Zhao,Nagarathanam Veerasamy,Kyu Ok Jeon,Jonathan J. Mills,Zhiguo Bian,John Sensintaffar,Allison L. Arnold,Stuart A. Fogarty,Evan Perry,Haley E. Ramsey,Rebecca S. Cook,Melinda Hollingshead,Myrtle Davis Millin,Kyungmin Lee,Brian Koss,Amit Budhraja,Joseph T. Opferman,Kwangho Kim,Carlos L. Arteaga,William J. Moore,Edward T. Olejniczak,Michael R. Savona,Stephen W. Fesik +26 more
TL;DR: The use of structure-based design is described to discover a novel compound that robustly and specifically inhibits Mcl-1 in cell culture and animal xenograft models and support the use of 42 as a potential treatment strategy to block MCl-1 activity and induce apoptosis in M cl-1-dependent cancers.
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Optimized constant-time 4D HNCAHA and HN(CO)CAHA experiments. Applications to the backbone assignments of the FKBP/ascomycin complex
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A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A.
Elaine M. Souza-Fagundes,Andreas O. Frank,Michael D. Feldkamp,Daniel C. Dorset,Walter J. Chazin,Walter J. Chazin,Olivia W. Rossanese,Edward T. Olejniczak,Stephen W. Fesik,Stephen W. Fesik +9 more
TL;DR: A homogeneous, high-throughput fluorescence polarization assay for identifying compounds that block the critical protein-protein interaction site in the basic cleft of the 70N domain of RPA (RPA70N).
Journal ArticleDOI
pH Titration of the histidine residues of cyclophilin and FK506 binding protein in the absence and presence of immunosuppressant ligands
Liping Yu,Stephen W. Fesik +1 more
TL;DR: The pKa values of the histidine imidazole rings are higher than the pKa's obtained for the peptidyl prolyl cis-trans isomerase (PPiase) activity of these enzymes, indicating that the acid/base characters of His-87 of FKBP and His-126 of CyP are not essential in the PPiase catalysis.