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Stephen W. Fesik
Researcher at Vanderbilt University
Publications - 298
Citations - 42613
Stephen W. Fesik is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Binding site. The author has an hindex of 95, co-authored 294 publications receiving 40006 citations. Previous affiliations of Stephen W. Fesik include Howard Hughes Medical Institute & Yale University.
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Structural biology of the Bcl-2 family of proteins.
TL;DR: The recently determined structure of the anti-apoptotic Bcl-w protein, the protein was also found to have a hydrophobic groove on its surface capable of binding BH3-containing proteins and peptides, which may explain why it is found predominately in the cytoplasm prior to activation.
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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
Zhihong Liu,Chaohong Sun,Edward T. Olejniczak,Robert P. Meadows,Stephen F. Betz,Thorsten Oost,Julia Herrmann,Joe C. Wu,Stephen W. Fesik +8 more
TL;DR: The solution structure of the BIR3 domain of X-linked IAP (XIAP) complexed with a functionally active nine-residue peptide derived from the N terminus of Smac is determined and should aid in the design of small molecules that may be used for the treatment of cancers that overexpress IAPs.
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14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation
Sandeep Robert Datta,Alexander Y. Katsov,Linda Hu,Andrew M. Petros,Stephen W. Fesik,Michael B. Yaffe,Michael E. Greenberg +6 more
TL;DR: In this paper, survival factors trigger the phosphorylation of the pro-apoptotic Bcl-2 family member BAD at a site (Ser-155) within the BAD BH3 domain.
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Twenty years on: the impact of fragments on drug discovery.
TL;DR: How to design fragment libraries, how to select screening techniques and how to make the most of information gleaned from them are discussed, and how concepts from FBDD have permeated and enhanced drug discovery efforts are shown.
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Specificity of short interfering RNA determined through gene expression signatures
Dimitri Semizarov,Leigh Frost,Aparna Sarthy,Paul E. Kroeger,Donald N. Halbert,Stephen W. Fesik +5 more
TL;DR: The results indicate that siRNA is a highly specific tool for targeted gene knockdown, establishing siRNA-mediated gene silencing as a reliable approach for large-scale screening of gene function and drug target validation.