R
Rita Derua
Researcher at Katholieke Universiteit Leuven
Publications - 110
Citations - 4849
Rita Derua is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Phosphorylation & Medicine. The author has an hindex of 36, co-authored 93 publications receiving 4001 citations. Previous affiliations of Rita Derua include Brown University & The Catholic University of America.
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Journal ArticleDOI
De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Evelien Rysman,Koen Brusselmans,Katryn Scheys,Leen Timmermans,Rita Derua,Sebastian Munck,Paul P. Van Veldhoven,David Waltregny,Veerle W. Daniels,Jelle Machiels,Frank Vanderhoydonc,Karine Smans,Etienne Waelkens,Guido Verhoeven,Johannes V. Swinnen +14 more
TL;DR: Evidence is provided that shifting lipid acquisition from lipid uptake toward de novo lipogenesis dramatically changes membrane properties and protects cells from both endogenous and exogenous insults, and provides a rationale for the use of lipogenesis inhibitors as antineoplastic agents and as chemotherapeutic sensitizers.
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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
Kim Vriens,Stefan Christen,Sweta Parik,Dorien Broekaert,Kazuaki Yoshinaga,Ali Talebi,Jonas Dehairs,Carmen Escalona-Noguero,Roberta Schmieder,Thomas Cornfield,Catriona Charlton,Laura Romero-Pérez,Matteo Rossi,Gianmarco Rinaldi,Martin F. Orth,Ruben Boon,Axelle Kerstens,Suet Ying Kwan,Brandon Faubert,Andrés Méndez-Lucas,Charlotte Kopitz,Ting Chen,Juan Fernández-García,Joao A.G. Duarte,Arndt Schmitz,Patrick Steigemann,Mustapha Najimi,Andrea Hägebarth,Jo A. Van Ginderachter,Etienne Sokal,Naohiro Gotoh,Kwok-Kin Wong,Catherine M. Verfaillie,Rita Derua,Sebastian Munck,Mariia Yuneva,Laura Beretta,Ralph J. DeBerardinis,Johannes V. Swinnen,Leanne Hodson,David Cassiman,Chris Verslype,Sven Christian,Sylvia Grünewald,Thomas G. P. Grunewald,Sarah-Maria Fendt +45 more
TL;DR: In several human and mouse cancer cell lines and carcinomas, a sapienate biosynthesis pathway underpins metabolic plasticity by allowing these cells to bypass stearoyl-CoA desaturase-dependent fatty acid desaturation.
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Identification of the gregarization-associated dark-pigmentotropin in locusts through an albino mutant
Amer I. Tawfik,Seiji Tanaka,Arnold De Loof,Liliane Schoofs,Geert Baggerman,Etienne Waelkens,Rita Derua,Yoram Milner,Yoram Yerushalmi,M. Paul Pener +9 more
TL;DR: Results show that even in isolated (solitary) nymphs, [His7] corazonin induces gregarious black patterns, and its primary structure shows some similarity with the vertebrate melanophore stimulating hormone.
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Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool
Ragna Sannerud,Cary Esselens,Paulina Ejsmont,Rafael Mattera,Leila Rochin,Leila Rochin,Arun Kumar Tharkeshwar,Greet De Baets,Veerle De Wever,Roger Habets,Veerle Baert,Wendy Vermeire,Christine Michiels,Arjan J. Groot,Rosanne Wouters,Katleen Dillen,Katlijn Vints,Pieter Baatsen,Sebastian Munck,Rita Derua,Etienne Waelkens,Guriqbal S. Basi,M Mercken,Marc Vooijs,Mathieu Bollen,Joost Schymkowitz,Frederic Rousseau,Juan S. Bonifacino,Guillaume van Niel,Guillaume van Niel,Bart De Strooper,Bart De Strooper,Wim Annaert +32 more
TL;DR: In this article, the authors examined the significance of this heterogeneity and identified a unique motif in PSEN2 that directs this γ-secretase to late endosomes/lysosomes via a phosphorylationdependent interaction with the AP-1 adaptor complex.
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Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
TL;DR: Sequence analysis shows that the novel methyltransferase is distinct from other known protein methyltransferases, sharing only sequence motifs supposedly involved in the binding of adenosylmethionine.