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Steven R. Leong
Researcher at Genentech
Publications - 44
Citations - 3645
Steven R. Leong is an academic researcher from Genentech. The author has contributed to research in topics: Monoclonal antibody & Antibody. The author has an hindex of 23, co-authored 41 publications receiving 3535 citations. Previous affiliations of Steven R. Leong include Indiana University – Purdue University Indianapolis.
Papers
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Journal ArticleDOI
Structure and function of lipopolysaccharide binding protein
R R Schumann,Steven R. Leong,Gail W. Flaggs,Patrick W. Gray,Samuel D. Wright,John C. Mathison,Peter S. Tobias,Richard J. Ulevitch +7 more
TL;DR: The identification of this pathway for LPS-induced monocyte stimulation may aid in the development of treatments for diseases in which Gram-negative sepsis or endotoxemia are involved.
Journal ArticleDOI
Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations.
TL;DR: The amino-terminal end of BPI exhibits significant similarity with the sequence of a rabbit lipopolysaccharide-binding protein, suggesting that both molecules share a similar structure for binding lipopolySaccharides.
Journal ArticleDOI
Complete mutagenesis of the extracellular domain of interleukin-8 (IL-8) type A receptor identifies charged residues mediating IL-8 binding and signal transduction.
TL;DR: The study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199,Arg-203, and Asp-265, are important for IL-8 binding andIL-8-mediated signal transduction.
Journal ArticleDOI
Mutational analysis of the intracellular domain of the human growth hormone receptor.
TL;DR: It is found that truncated GH receptors containing as few as 54 amino acids of the cytoplasmic domain are able to transmit a GH proliferative signal; thus, at least 84% of the intracellular domain is unnecessary for signaling in this system.
Patent
Humanized anti-IL-8 monoclonal antibodies
TL;DR: In this paper, a humanized anti-IL-8 monoclonal antibody and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders, and a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer is described.