S
Stewart D. Clark
Researcher at University at Buffalo
Publications - 40
Citations - 2239
Stewart D. Clark is an academic researcher from University at Buffalo. The author has contributed to research in topics: Cholinergic & Neuropeptide S. The author has an hindex of 20, co-authored 39 publications receiving 1999 citations. Previous affiliations of Stewart D. Clark include Centre for Addiction and Mental Health & State University of New York System.
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Journal ArticleDOI
Neuropeptide S: A Neuropeptide Promoting Arousal and Anxiolytic-like Effects
Yan Ling Xu,Rainer K. Reinscheid,Salvador Huitron-Resendiz,Stewart D. Clark,Zhiwei Wang,Steven H.S. Lin,Fernando A. Brucher,Joanne Zeng,Nga Kim Ly,Steven J. Henriksen,Luis de Lecea,Olivier Civelli +11 more
TL;DR: It is reported that a neuropeptide, NPS, potently modulates wakefulness and could also regulate anxiety, and it is shown that the LC region encompasses distinct nuclei expressing different arousal-promoting neurotransmitters.
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Clozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments.
Duncan A. A. MacLaren,Richard W. Browne,Jessica K. Shaw,Sandhya Krishnan Radhakrishnan,Prachi Khare,Rodrigo A. España,Stewart D. Clark +6 more
TL;DR: The results show that CNO has multiple dose-dependent effects in vivo and is converted to clozapine and N-Des emphasizing the need for a CNO-only DreadD-free control group when designing DREADD-based experiments.
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Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala.
Kay Jüngling,Thomas Seidenbecher,Ludmila Sosulina,Jörg Lesting,Susan Sangha,Stewart D. Clark,Naoe Okamura,Dee M. Duangdao,Yan Ling Xu,Rainer K. Reinscheid,Hans-Christian Pape +10 more
TL;DR: Mechanisms of NPS in the brain, a key role of intercalated neurons in the amygdala for fear extinction, and a potential pharmacological avenue for treating anxiety disorders are identified.
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Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain
Naoe Okamura,Celia Garau,Dee M. Duangdao,Stewart D. Clark,Kay Jüngling,Hans-Christian Pape,Rainer K. Reinscheid +6 more
TL;DR: Evidence is provided for a facilitatory role of NPS in long-term memory, independent of memory content, possibly by acting as a salience signal or as an arousal-promoting factor.
Journal ArticleDOI
Anatomical characterization of the neuropeptide S system in the mouse brain by in situ hybridization and immunohistochemistry.
Stewart D. Clark,Dee M. Duangdao,Stefan Schulz,Li Zhang,Xiaobin Liu,Yan-Ling Xu,Rainer K. Reinscheid +6 more
TL;DR: A comprehensive map of NPS precursor and receptor mRNA expression in the mouse brain is reported, demonstrating that the distribution pattern of the central NPS system is only partially conserved between mice and rats.