S
Stewart Sale
Researcher at University of Leicester
Publications - 20
Citations - 1263
Stewart Sale is an academic researcher from University of Leicester. The author has contributed to research in topics: In vivo & Resveratrol. The author has an hindex of 14, co-authored 20 publications receiving 1177 citations. Previous affiliations of Stewart Sale include Leicester Royal Infirmary.
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Journal ArticleDOI
Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene.
Stewart Sale,Richard D. Verschoyle,David J. Boocock,Donald J. L. Jones,N. Wilsher,Ketan C. Ruparelia,Gerry A. Potter,Peter B. Farmer,William P. Steward,Andreas J. Gescher +9 more
TL;DR: Results provide a good rationale to evaluate DMU 212 as a colorectal cancer chemopreventive agent and show preferential growth-inhibitory and proapoptotic properties in transformed cells, when compared with their untransformed counterparts.
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Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells.
Matthew S. Squires,E Ann Hudson,Lynne M. Howells,Stewart Sale,C. E. Houghton,J. Louise Jones,Louise H. Fox,Martin Dickens,Sally A. Prigent,Margaret M. Manson +9 more
TL;DR: While curcumin has several different molecular targets within the MAPK and PI3K/PKB signalling pathways that could contribute to inhibition of proliferation and induction of apoptosis, inhibition of basal activity of Akt/P KB, but not ERK, may facilitate apoptosis in the tumour cell line.
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Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells.
Stewart Sale,Richard G. Tunstall,Ketan C. Ruparelia,Gerry A. Potter,William P. Steward,Andreas J. Gescher +5 more
TL;DR: Results suggest that alteration of the resveratrol molecule to generate DMU‐212 does not abrogate its ability to decrease adenoma number in ApcMin+ mice or to interfere with PGE‐2 generation in cells.
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Sulfate Metabolites Provide an Intracellular Pool for Resveratrol Generation and Induce Autophagy with Senescence
Ketan R. Patel,Catherine Andreadi,Robert G. Britton,Emma Horner-Glister,Ankur Karmokar,Stewart Sale,Victoria A. Brown,Dean E. Brenner,Rajinder Singh,William P. Steward,Andreas J. Gescher,Karen Brown +11 more
TL;DR: The findings suggest that resveratrol is delivered to target tissues in a stable sulfate-conjugated form and that the parent compound is gradually regenerated in selected cells and may give rise to the beneficial effects in vivo.
Journal ArticleDOI
Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.
Glen R.B. Irving,Lynne M. Howells,Stewart Sale,Ines Kralj-Hans,Wendy Atkin,Susan K. Clark,Robert G. Britton,Donald J. L. Jones,Edwina N. Scott,David P. Berry,David Hemingway,Andrew S. Miller,Karen Brown,Andreas J. Gescher,William P. Steward +14 more
TL;DR: Levels of pharmacologically active levels of curcumin were recovered from colonic mucosa of patients undergoing colorectal endoscopy or surgical resection and information on the acceptability and compliance with dailyCurcumin was obtained.