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Stuart Firestein
Researcher at Columbia University
Publications - 120
Citations - 10377
Stuart Firestein is an academic researcher from Columbia University. The author has contributed to research in topics: Olfactory system & Olfactory receptor. The author has an hindex of 47, co-authored 117 publications receiving 9499 citations. Previous affiliations of Stuart Firestein include University of Lausanne & Fairchild Semiconductor International, Inc..
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Journal ArticleDOI
How the olfactory system makes sense of scents
TL;DR: Growing interest in the detection of diverse compounds at single-molecule levels has made the olfactory system an important system for biological modelling.
Journal ArticleDOI
The olfactory receptor gene superfamily of the mouse.
Xinmin Zhang,Stuart Firestein +1 more
TL;DR: Human ORs cover a similar 'receptor space' as the mouse ORs, suggesting that the human olfactory system has retained the ability to recognize a broad spectrum of chemicals even though humans have lost nearly two-thirds of the OR genes as compared to mice.
Journal ArticleDOI
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
Jennifer L. Pluznick,Ryan J. Protzko,Haykanush Gevorgyan,Zita Peterlin,Arnold Sipos,Jinah Han,Isabelle Brunet,La Xiang Wan,Federico E. Rey,Tong Wang,Stuart Firestein,Masashi Yanagisawa,Jeffrey I. Gordon,Anne Eichmann,János Peti-Peterdi,Michael J. Caplan +15 more
TL;DR: It is found that Olfr78, an olfactory receptor expressed in the kidney, responds to short chain fatty acids (SCFAs), and SCFAs produced by the gut microbiota modulate blood pressure via OlfR78 and Gpr41.
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Functional expression of a mammalian odorant receptor
Haiqing Zhao,Lidija Ivic,Lidija Ivic,Joji M. Otaki,Joji M. Otaki,Mitsuhiro Hashimoto,Mitsuhiro Hashimoto,Katsuhiro Mikoshiba,Katsuhiro Mikoshiba,Stuart Firestein,Stuart Firestein +10 more
TL;DR: Electrophysiological recording showed that increased expression of a single gene led to greater sensitivity to a small subset of odorants in the rat olfactory epithelium.
Journal ArticleDOI
The molecular receptive range of an odorant receptor
TL;DR: A pharmacological approach that uses a large and diverse pool of odorous compounds to characterize the molecular receptive field of an odor receptor found a high specificity for certain molecular features, but high tolerance for others—a strategy that enables the olfactory apparatus to be both highly discriminating, and able to recognize several thousand Odorous compounds.