János Peti-Peterdi

TL;DR: It is found that Olfr78, an olfactory receptor expressed in the kidney, responds to short chain fatty acids (SCFAs), and SCFAs produced by the gut microbiota modulate blood pressure via OlfR78 and Gpr41.

TL;DR: Results suggest that AngII directly stimulates Na(+) channel activity in the CCD, and Regulation of ENaC activity by AngII may play an important role in distal Na(+) reabsorption in health and disease.

TL;DR: A paracrine signaling pathway in the kidney in which high levels of glucose directly triggered the release of the prohypertensive hormone renin is identified, which may serve to modulate kidney function and help remove metabolic waste products through renal hyperfiltration and link metabolic diseases with RAS overactivation, systemic hypertension, and organ injury.

TL;DR: Cell-to-cell communication between macula densa cells and mesangial cells, which express P2Y2 receptors, involves the release of ATP from macula densitya cells via maxi anion channels at the basolateral membrane, which may represent a new paradigm in cell- to-cell signal transduction mediated by ATP.

TL;DR: Using Munich-Wistar-Fromter rats as a model of spontaneous albuminuric CKD, multiphoton fluorescence imaging and single-vessel physiology measurements suggest that widespread loss of the endothelial surface layer links albuminuria and CKD with systemic vascular dysfunction, providing a potential therapeutic target for proteinuric kidney disease.