Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
Jennifer L. Pluznick,Ryan J. Protzko,Haykanush Gevorgyan,Zita Peterlin,Arnold Sipos,Jinah Han,Isabelle Brunet,La Xiang Wan,Federico E. Rey,Tong Wang,Stuart Firestein,Masashi Yanagisawa,Jeffrey I. Gordon,Anne Eichmann,János Peti-Peterdi,Michael J. Caplan +15 more
TLDR
It is found that Olfr78, an olfactory receptor expressed in the kidney, responds to short chain fatty acids (SCFAs), and SCFAs produced by the gut microbiota modulate blood pressure via OlfR78 and Gpr41.Abstract:
Olfactory receptors are G protein-coupled receptors that mediate olfactory chemosensation and serve as chemosensors in other tissues. We find that Olfr78, an olfactory receptor expressed in the kidney, responds to short chain fatty acids (SCFAs). Olfr78 is expressed in the renal juxtaglomerular apparatus, where it mediates renin secretion in response to SCFAs. In addition, both Olfr78 and G protein-coupled receptor 41 (Gpr41), another SCFA receptor, are expressed in smooth muscle cells of small resistance vessels. Propionate, a SCFA shown to induce vasodilation ex vivo, produces an acute hypotensive response in wild-type mice. This effect is differentially modulated by disruption of Olfr78 and Gpr41 expression. SCFAs are end products of fermentation by the gut microbiota and are absorbed into the circulation. Antibiotic treatment reduces the biomass of the gut microbiota and elevates blood pressure in Olfr78 knockout mice. We conclude that SCFAs produced by the gut microbiota modulate blood pressure via Olfr78 and Gpr41.read more
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Journal ArticleDOI
Gut microbiota, metabolites and host immunity
TL;DR: Technological and computational approaches for investigating the microbiome, as well as recent advances in the understanding of host immunity and microbial mutualism are discussed with a focus on specific microbial metabolites, bacterial components and the immune system.
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The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Journal ArticleDOI
Short-chain Fatty Acids in Control of Body Weight and Insulin Sensitivity
TL;DR: This Review discusses the effects of three SCFA on energy homeostasis and metabolism, as well as how these SCFA can beneficially modulate adipose tissue, skeletal muscle and liver tissue function and the increasing evidence for a potential role of SCFA as metabolic targets to prevent and counteract obesity.
Journal ArticleDOI
The role of short-chain fatty acids in microbiota-gut-brain communication.
TL;DR: This Review summarizes existing knowledge on the potential of SCFAs to directly or indirectly mediate microbiota–gut–brain interactions and their interaction with gut–brain signalling pathways including immune, endocrine, neural and humoral routes.
Journal ArticleDOI
Gut Dysbiosis Is Linked to Hypertension
Tao Yang,Monica M Santisteban,Vermali Rodriguez,Eric Li,Niousha Ahmari,Jessica Marulanda Carvajal,Mojgan Zadeh,Minghao Gong,Yanfei Qi,Jasenka Zubcevic,Bikash Sahay,Carl J. Pepine,Mohan K. Raizada,Mansour Mohamadzadeh +13 more
TL;DR: It is demonstrated that high blood pressure is associated with gut microbiota dysbiosis, both in animal and human hypertension, and dietary intervention to correct gut microbiota could be an innovative nutritional therapeutic strategy for hypertension.
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