S
Stuart L. Schreiber
Researcher at Broad Institute
Publications - 58
Citations - 6421
Stuart L. Schreiber is an academic researcher from Broad Institute. The author has contributed to research in topics: Nucleophile & Coupling reaction. The author has an hindex of 33, co-authored 58 publications receiving 5902 citations. Previous affiliations of Stuart L. Schreiber include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
Lakshmi Raj,Takao Ide,Aditi U. Gurkar,Michael Foley,Monica Schenone,Xiaoyu Li,Nicola Tolliday,Todd R. Golub,Steven A. Carr,Alykhan F. Shamji,Andrew M. Stern,Anna Mandinova,Anna Mandinova,Stuart L. Schreiber,Sam W. Lee,Sam W. Lee +15 more
TL;DR: The ability of a small molecule to induce apoptosis selectively in cells that have a cancer genotypes is demonstrated, by targeting a non-oncogene co-dependency acquired through the expression of the cancer genotype in response to transformation-induced oxidative stress.
Journal ArticleDOI
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
Sovan Sarkar,Ethan O. Perlstein,Ethan O. Perlstein,Sara Imarisio,Sandra Pineau,Axelle Cordenier,Rebecca L Maglathlin,John A Webster,Timothy A. Lewis,Cahir J. O'Kane,Stuart L. Schreiber,Stuart L. Schreiber,David C. Rubinsztein +12 more
TL;DR: Proof of principle is demonstrated for a new approach for discovery of small-molecule modulators of mammalian autophagy for therapeutic potential in Huntington's disease cell and Drosophila melanogaster models.
Journal ArticleDOI
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Matthew G. Rees,Brinton Seashore-Ludlow,Brinton Seashore-Ludlow,Jaime H. Cheah,Jaime H. Cheah,Drew J. Adams,Drew J. Adams,Edmund Price,Edmund Price,Shubhroz Gill,Sarah Javaid,Matthew E. Coletti,Victor Victor Jones,Nicole E. Bodycombe,Nicole E. Bodycombe,Christian K Soule,Christian K Soule,Benjamin Alexander,Ava Li,Philip Montgomery,Joanne Kotz,C. Suk-Yee Hon,Benito Munoz,Ted Liefeld,Ted Liefeld,Vlado Dančík,Daniel A. Haber,Clary B. Clish,Joshua A. Bittker,Michelle Palmer,Michelle Palmer,Bridget K. Wagner,Paul A. Clemons,Alykhan F. Shamji,Stuart L. Schreiber +34 more
TL;DR: It is found that ML239, originally identified in a phenotypic screen for selective cytotoxicity in breast cancer stem-like cells, most likely acts through activation of fatty acid desaturase 2 (FADS2).
Journal ArticleDOI
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.
Christina M. Grozinger,Elizabeth D. Chao,Helen E. Blackwell,Danesh Moazed,Stuart L. Schreiber +4 more
TL;DR: A high throughput, phenotypic screen in cells that led to the discovery of a class of sirtuin inhibitors, and structure-activity relationship analysis of the compounds identified a key hydroxy-napthaldehyde moiety that is necessary and sufficient for inhibitory activity.
Journal ArticleDOI
Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells
Malgorzata Borowiak,René Maehr,René Maehr,Shuibing Chen,Shuibing Chen,Alice E. Chen,Alice E. Chen,Weiping Tang,Julia L. Fox,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,Douglas A. Melton,Douglas A. Melton +13 more
TL;DR: The application of small molecules to differentiate mouse and human ESCs into endoderm represents a step toward achieving a reproducible and efficient production of desired ESC derivatives.