Su Chu

TL;DR: Investigation of the role of Grb2 in CML progenitor transformation by cotransducing human CD34+ cells with lentivirus vectors expressing short hairpin RNA to Grb 2 and retrovirus vectorsexpressing BCR/ABL shows that inhibition ofgrb2 expression demonstrates an important role in BCR–ABL-mediated MAPK activation and transformation of primary human hematopoietic cells.

TL;DR: In this article, the authors studied the mechanisms of acquired resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors (TKIs) by examining genome-wide gene expression changes in KCL-22 CML cells versus their resistant KCL -22M cells that acquire T315I BCR-ABL mutation following TKI exposure.

TL;DR: The studies show the importance of BCR-ABL-Y177-AKT-mediated p27 phosphorylation in altered p27 localization and enhanced proliferation and expansion of primary CML progenitors.

TL;DR: The results demonstrate the potent preclinical antileukemic activity of ARTS as well as its potential for a rapid transition to a clinical trial either alone or in combination with conventional chemotherapy or BCL-2 inhibitor, for treatment of AML.

TL;DR: The results clearly demonstrate the persistence of Bcr-Abl+ stem cells in the BM of CML patients in prolonged remission after 5 years of IM treatment, and raises the concern that patients remain at risk for relapse on drug discontinuation.