W
WenYong Chen
Researcher at City of Hope National Medical Center
Publications - 16
Citations - 1435
WenYong Chen is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Chronic myelogenous leukemia & Imatinib. The author has an hindex of 10, co-authored 16 publications receiving 1298 citations. Previous affiliations of WenYong Chen include Beckman Research Institute.
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Journal ArticleDOI
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
Ling Li,Lisheng Wang,Liang Li,Zhiqiang Wang,YinWei Ho,Tinisha McDonald,Tessa L. Holyoake,WenYong Chen,Ravi Bhatia +8 more
TL;DR: It is shown that the NAD(+)-dependent deacetylase SIRT1 is overexpressed in human CML LSC and Activation of p53 via Sirt1 inhibition represents a potential approach to target C ML LSC.
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NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response
TL;DR: It is demonstrated that in addition to modulating SIRT1 functions, the NAMPT inhibition reduces forkhead box, class ‘O’ (FOXO)3a protein expression and its downstream anti-oxidant genes catalase and manganese superoxide dismutase.
Journal ArticleDOI
Sorting out functions of sirtuins in cancer
Mendel Roth,WenYong Chen +1 more
TL;DR: The bifurcated roles of SIRT1, and perhaps several other sirtuins, in cancer may be in part a result of the nature of the genes that are involved in the cell’s genome maintenance systems.
Journal ArticleDOI
SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells
Ling Li,Tereza Osdal,YinWei Ho,Sookhee Chun,Tinisha McDonald,Puneet Agarwal,Allen Lin,Su Chu,Jing Qi,Liang Li,Yao-Te Hsieh,Cedric Dos Santos,Hongfeng Yuan,Trung-Quang Ha,Mihaela Popa,Randi Hovland,Øystein Bruserud,Øystein Bruserud,Bjørn Tore Gjertsen,Bjørn Tore Gjertsen,Ya-Huei Kuo,WenYong Chen,Sonia Lain,Emmet McCormack,Emmet McCormack,Ravi Bhatia +25 more
TL;DR: It is shown that the NAD-dependent SIRT1 deacetylase is selectively overexpressed in primary human FLT3-ITD AML LSCs and contributes to their maintenance.
Journal ArticleDOI
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
Hongfeng Yuan,Zhiqiang Wang,Ling Li,Hao Zhang,Hardik Modi,David Horne,Ravi Bhatia,WenYong Chen +7 more
TL;DR: SIRT1 is a novel survival pathway activated by BCR-ABL expression in hematopoietic progenitor cells, which promotes oncogenic transformation and leukemogenesis and is suggested to be a therapeutic target for CML treatment to overcome resistance.