Subhadip Kundu

TL;DR: Results suggest a critical role for JNK and p53 in RAPTA-C-induced G2/M arrest and apoptosis of EAC-bearing mice, which results in a significant inhibition in the progression of cancer in an animal model, which emulates the human disease, and does so with remarkably low general toxicity; hence, RAPta-C has potential for clinical application.

TL;DR: The results prove that cadmium causes both inflammation and cell proliferation when applied in a low dose but proliferative changes occur independent of inflammation.

TL;DR: It is shown that cadmium induced p53-dependent apoptosis through cooperation between Bcl-xl down regulation without changing the B cl-2 and Bax expression, the common target of p53, strongly indicating mitochondrial involvement in apoptosis.

TL;DR: NC525 as discussed by the authors is a humanized immunoglobulin gamma 1, kappa (IgG1κ) monoclonal antibody that targets LAIR-1-expressing AML blasts and leukemic stem cells.

TL;DR: Traboulsi et al. as mentioned in this paper showed that PARP inhibition can enhance the number and cytotoxicity of antigen-specific CD8 T cells and the maintenance of memory population within the tumor microenvironment.