D
Dallas B. Flies
Researcher at Yale University
Publications - 61
Citations - 16382
Dallas B. Flies is an academic researcher from Yale University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 35, co-authored 56 publications receiving 14468 citations. Previous affiliations of Dallas B. Flies include University of Minnesota & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
Haidong Dong,Scott E. Strome,Diva R. Salomao,Hideto Tamura,Fumiya Hirano,Dallas B. Flies,Patrick C. Roche,Jun Lu,Gefeng Zhu,Koji Tamada,Vanda A. Lennon,Esteban Celis,Lieping Chen +12 more
TL;DR: It is reported here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1 and the findings have implications for the design of T cell–based cancer immunotherapy.
Journal ArticleDOI
Molecular mechanisms of T cell co-stimulation and co-inhibition
TL;DR: The mechanisms through which T cell activation, differentiation and function is controlled by co-stimulatory and co-inhibitory receptors are reviewed.
Journal ArticleDOI
Role of LAG-3 in regulatory T cells.
Ching Tai Huang,Creg J. Workman,Dallas B. Flies,Xiaoyu Pan,Aimee L. Marson,Gang Zhou,Edward L. Hipkiss,Sowmya Ravi,Jeanne Kowalski,Hyam I. Levitsky,Jonathan D. Powell,Drew M. Pardoll,Charles G. Drake,Dario A. A. Vignali +13 more
TL;DR: It is proposed that LAG-3 marks regulatory T cell populations and contributes to their suppressor activity, which reduces their proliferative capacity and confers on them suppressionor activity toward effector T cells.
Journal Article
Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity
Fumiya Hirano,Katsumi Kaneko,Hideto Tamura,Haidong Dong,Shengdian Wang,Shengdian Wang,Masao Ichikawa,Masao Ichikawa,Cecilia Rietz,Cecilia Rietz,Dallas B. Flies,Dallas B. Flies,Julie S. Lau,Gefeng Zhu,Gefeng Zhu,Koji Tamada,Koji Tamada,Lieping Chen,Lieping Chen +18 more
TL;DR: It is reported here that constitutive or inducible expression of B7-H1, a B7 family molecule widely expressed by cancers, confers resistance to therapeutic anti-CD137 antibody in mice with established tumors and implicate new approaches for immunotherapy of human cancers.
Journal ArticleDOI
B7-H3: A costimulatory molecule for T cell activation and IFN-γ production
Andrei I. Chapoval,Jian Ni,Julie S. Lau,Ryan A. Wilcox,Dallas B. Flies,Ding Liu,Haidong Dong,Gabriel Sica,Gefeng Zhu,Koji Tamada,Lieping Chen +10 more
TL;DR: A newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20–27% amino acid identity with other B7family members is described, that may participate in the regulation of cell-mediated immune responses.