Subhadra C. Gunawardana

TL;DR: It is shown that adipocyte-specific deletion of the coregulatory protein PRDM16 caused minimal effects on classical brown fat but markedly inhibited beige adipocyte function in subcutaneous fat following cold exposure or β3-agonist treatment, indicating that PRDM 16 and beige fat cells are required for the "browning" of white fat and the healthful effects of sub cutaneous adipose tissue.

TL;DR: This study finds a direct link between elevated serum cholesterol and reduced insulin secretion from pancreatic β-cells, with normal secretion restored by cholesterol depletion, and demonstrates that excess cholesterol inhibits secretion by downregulation of metabolism through increased neuronal nitric oxide synthase dimerization.

TL;DR: It is proposed that the combined action of multiple adipokines establishes a new equilibrium in the animal that allows for chronic glycemic control without insulin, and this work shows that subcutaneous transplants of embryonic brown adipose tissue (BAT) can correct T1D in streptozotocin-treated mice with severely impaired glucose tolerance and significant loss of adiposity.

TL;DR: The potential for insulin-independent reversal of autoimmune-induced T1D with BAT transplants is demonstrated and IGF-I is implicate as a likely mediator in the resulting equilibrium.

TL;DR: Recent studies on mouse models show that type 1 diabetes can be reversed without insulin through subcutaneous transplantation of embryonic brown adipose tissue, which leads to replenishment of recipients' white adipose tissues; increase of a number of beneficial adipokines; and fast and long-lasting euglycemia.