S
Sudha Singh
Researcher at University of New Mexico
Publications - 27
Citations - 5083
Sudha Singh is an academic researcher from University of New Mexico. The author has contributed to research in topics: Autophagy & Phagosome maturation. The author has an hindex of 14, co-authored 19 publications receiving 4740 citations. Previous affiliations of Sudha Singh include University of Florida.
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Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.
Maximiliano G. Gutierrez,Sharon Master,Sudha Singh,Gregory A. Taylor,María Isabel Colombo,Vojo Deretic +5 more
TL;DR: It is demonstrated that autophagic pathways can overcome the trafficking block imposed by M. tuberculosis, which is a hormonally, developmentally, and immunologically regulated process, represents an underapp appreciated innate defense mechanism for control of intracellular pathogens.
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Human IRGM induces autophagy to eliminate intracellular mycobacteria.
TL;DR: It is found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis.
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Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
George B. Kyei,Christina Dinkins,Alexander S Davis,Esteban A. Roberts,Sudha Singh,Chunsheng Dong,Li-Li Wu,Eiki Kominami,Takashi Ueno,Akitsugu Yamamoto,Maurizio Federico,Antonito T. Panganiban,Isabelle Vergne,Vojo Deretic +13 more
TL;DR: This work finds that autophagy intersects with human immunodeficiency virus (HIV) biogenesis, mirroring the above dichotomy, and enhances viral yields by using the early stages while inhibiting the late stages of autophagic activity.
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Cell biology of mycobacterium tuberculosis phagosome.
TL;DR: The fundamental trafficking processes targeted by M. tuberculosis and the mycobacterial products that interfere with phagosomal maturation are reviewed.
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Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism
Vojo Deretic,Sudha Singh,Sharon Master,James Harris,Esteban A. Roberts,George B. Kyei,Alexander S Davis,Sergio de Haro,John Naylor,Huang Ho Lee,Isabelle Vergne +10 more
TL;DR: This review summarizes the findings centred around the PI3P‐nexus where the mycobacterial phagosome maturation block and execution stages of autophagy intersect.