S
Sharon Master
Researcher at University of New Mexico
Publications - 24
Citations - 5394
Sharon Master is an academic researcher from University of New Mexico. The author has contributed to research in topics: Autophagy & Phagosome. The author has an hindex of 21, co-authored 24 publications receiving 5035 citations. Previous affiliations of Sharon Master include University of Michigan.
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Journal ArticleDOI
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.
Maximiliano G. Gutierrez,Sharon Master,Sudha Singh,Gregory A. Taylor,María Isabel Colombo,Vojo Deretic +5 more
TL;DR: It is demonstrated that autophagic pathways can overcome the trafficking block imposed by M. tuberculosis, which is a hormonally, developmentally, and immunologically regulated process, represents an underapp appreciated innate defense mechanism for control of intracellular pathogens.
Journal ArticleDOI
TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation
Manohar Pilli,John Arko-Mensah,Marisa Ponpuak,Marisa Ponpuak,Esteban A. Roberts,Sharon Master,Michael A. Mandell,Nicolas Dupont,Wojciech Ornatowski,Shanya Jiang,Steven B. Bradfute,Jack-Ansgar Bruun,Tom Egil Hansen,Terje Johansen,Vojo Deretic +14 more
TL;DR: TBK-1 is a key regulator of immunological autophagy and is responsible for the maturation of autophagosomes into lytic bactericidal organelles.
Journal ArticleDOI
T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis.
James Harris,Sergio de Haro,Sharon Master,Joseph Keane,Esteban A. Roberts,Mónica A. Delgado,Vojo Deretic +6 more
TL;DR: It is reported that Th2 cytokines affect autophagy in macrophages and their ability to control intracellular M. tuberculosis and a mechanism through which Th1-Th2 polarization differentially affects the immune control of intrACEllular pathogens.
Journal ArticleDOI
Mycobacterium tuberculosis Prevents Inflammasome Activation
Sharon Master,Silvana K. Rampini,Alexander S Davis,Christine Keller,Stefan Ehlers,Burkhard Springer,Graham S. Timmins,Peter Sander,Vojo Deretic +8 more
TL;DR: A previously masked role for IL-1beta is uncovered in the control of Mtb and a mycobacterial system that prevents inflammasome activation and, therefore, IL- 1beta activation is uncovered.
Journal ArticleDOI
Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism
Vojo Deretic,Sudha Singh,Sharon Master,James Harris,Esteban A. Roberts,George B. Kyei,Alexander S Davis,Sergio de Haro,John Naylor,Huang Ho Lee,Isabelle Vergne +10 more
TL;DR: This review summarizes the findings centred around the PI3P‐nexus where the mycobacterial phagosome maturation block and execution stages of autophagy intersect.