Sue Burkhart-Kasch

TL;DR: It is clear that the strong dependence of results on the specific laboratory is itself dependent on the task in question, and laboratory environments probably can never be made sufficiently similar to guarantee identical results on aWide range of tests in a wide range of labs.

TL;DR: It is concluded that D2R-deficient mice are not a model of Parkinson’s disease and the interaction of multiple genetic factors in the analysis of complex behaviors in gene knock-out mice is highlighted.

TL;DR: This paper showed that dopamine signaling via D2 receptors is an essential component of the molecular pathway determining ethanol self-administration and sensitivity, and that D2-receptor-deficient mice showed a marked aversion to ethanol in these mice, relative to the high preference and consumption exhibited by wild-type littermates.

TL;DR: It is demonstrated that dopamine signaling via D 2 receptors is an essential component of the molecular pathway determining ethanol self-administration and sensitivity in D2-receptor-deficient mice.

TL;DR: Results demonstrate locomotor sensitization induced by EtOH, suggest independence of genetic determination of locomotor responses to acute and repeated EtOH exposure, and partially support a relationship between reduced sensitivity to the locomotor stimulant/sensitizing effects of EtOH and EtOH consumption.