S
Sujay Chattopadhyay
Researcher at University of Washington
Publications - 48
Citations - 2263
Sujay Chattopadhyay is an academic researcher from University of Washington. The author has contributed to research in topics: Chemistry & Engineering. The author has an hindex of 20, co-authored 22 publications receiving 1864 citations.
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Journal ArticleDOI
The Epidemic of Extended-Spectrum-β-Lactamase-Producing Escherichia coli ST131 Is Driven by a Single Highly Pathogenic Subclone, H30-Rx
Lance B. Price,Lance B. Price,James R. Johnson,Maliha Aziz,Maliha Aziz,Connie Clabots,Brian D. Johnston,Veronika Tchesnokova,Lora Nordstrom,Maria Billig,Sujay Chattopadhyay,Marc Stegger,Marc Stegger,Paal Skytt Andersen,Paal Skytt Andersen,Talima Pearson,Kim Riddell,Peggy Rogers,Delia Scholes,Barbara C. Kahl,Paul Keim,Paul Keim,Evgeni V. Sokurenko +22 more
TL;DR: P pulsed-field gel electrophoresis and whole-genome sequencing are applied to reconstruct the evolutionary history of the ST131 clone and suggest that the high prevalence of CTX-M-15 production among ST131 isolates is due primarily to the expansion of a single, highly virulent subclone, H30-Rx.
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Abrupt Emergence of a Single Dominant Multidrug-Resistant Strain of Escherichia coli
James R. Johnson,Veronika Tchesnokova,Brian D. Johnston,Connie Clabots,Pacita L. Roberts,Mariya Billig,Kim Riddell,Peggy Rogers,Xuan Qin,Susan M. Butler-Wu,Lance B. Price,Maliha Aziz,Marie-Hélène Nicolas-Chanoine,Chitrita DebRoy,Ari Robicsek,Glen Hansen,Carl Urban,Carl Urban,Joanne L. Platell,Darren J. Trott,George G. Zhanel,Scott J. Weissman,Brad T. Cookson,Ferric C. Fang,Ajit P. Limaye,Delia Scholes,Sujay Chattopadhyay,David C. Hooper,Evgeni V. Sokurenko +28 more
TL;DR: Most current fluoroquinolone-resistant E. coli clinical isolates represent a highly clonal subgroup that likely originated from a single rapidly expanded and disseminated ST131 strain, which expanded abruptly after 2000.
Journal ArticleDOI
High-resolution two-locus clonal typing of extraintestinal pathogenic Escherichia coli.
Scott J. Weissman,James R. Johnson,Veronika Tchesnokova,Mariya Billig,Daniel E. Dykhuizen,Kim Riddell,Peggy Rogers,Xuan Qin,Susan M. Butler-Wu,Brad T. Cookson,Ferric C. Fang,Delia Scholes,Sujay Chattopadhyay,Evgeni V. Sokurenko +13 more
TL;DR: This work describes a two-locus, sequence-based typing scheme for Escherichia coli that utilizes a 489-nucleotide (nt) internal fragment of fimH (encoding the type 1 fimbrial adhesin) and the 469-nt internal fumC fragment used in standard MLST.
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Point mutations in FimH adhesin of Crohn's disease-associated adherent-invasive Escherichia coli enhance intestinal inflammatory response.
Nicolas Dreux,Jérémy Denizot,Margarita Martinez-Medina,Alexander Mellmann,Maria Billig,Dagmara I. Kisiela,Sujay Chattopadhyay,Evgeni V. Sokurenko,Christel Neut,Corinne Gower-Rousseau,Jean-Frederic Colombel,Richard Bonnet,Arlette Darfeuille-Michaud,Nicolas Barnich +13 more
TL;DR: The results highlight a mechanism of AIEC virulence evolution that involves selection of amino acid mutations in the common bacterial traits, such as FimH protein, and leads to the development of chronic inflammatory bowel disease (IBD) in a genetically susceptible host.
Journal ArticleDOI
Accelerated gene evolution through replication-transcription conflicts
TL;DR: The findings indicate that head-on replication–transcription conflicts are more mutagenic than co-directional conflicts and that these encounters can significantly increase adaptive structural variation in the coded proteins.