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Alexander Mellmann
Researcher at University of Münster
Publications - 285
Citations - 13194
Alexander Mellmann is an academic researcher from University of Münster. The author has contributed to research in topics: Shiga toxin & Escherichia coli. The author has an hindex of 55, co-authored 247 publications receiving 11284 citations. Previous affiliations of Alexander Mellmann include University of Innsbruck.
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Journal ArticleDOI
Prospective Genomic Characterization of the German Enterohemorrhagic Escherichia coli O104:H4 Outbreak by Rapid Next Generation Sequencing Technology
Alexander Mellmann,Dag Harmsen,Craig Cummings,Emily B. Zentz,Shana R. Leopold,Alain Rico,Karola Prior,Rafael Szczepanowski,Yongmei Ji,Wenlan Zhang,Stephen F. McLaughlin,John K. Henkhaus,Benjamin Leopold,Martina Bielaszewska,Rita Prager,Pius Brzoska,Richard Moore,Simone Guenther,Jonathan M. Rothberg,Helge Karch +19 more
TL;DR: It is suggested that by stepwise gain and loss of chromosomal and plasmid-encoded virulence factors, a highly pathogenic hybrid of EAEC and EHEC emerged as the current outbreak clone.
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Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study
Martina Bielaszewska,Alexander Mellmann,Wenlan Zhang,Robin Köck,Angelika Fruth,Andreas Bauwens,Georg Peters,Helge Karch +7 more
TL;DR: Augmented adherence of the strain to intestinal epithelium might facilitate systemic absorption of Shiga toxin and could explain the high progression to haemolytic uraemic syndrome.
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Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx Nomenclature
Flemming Scheutz,Louise D. Teel,Lothar Beutin,Denis Pierard,Glenn Buvens,Helge Karch,Alexander Mellmann,Alfredo Caprioli,Rosangela Tozzoli,Stefano Morabito,Nancy A. Strockbine,Angela R. Melton-Celsa,Maria A. Sanchez,Søren Persson,Alison D. O'Brien +14 more
TL;DR: Using a consistent schema for nomenclature of the Stx toxins and stx genes by phylogenetic sequence-based relatedness of the holotoxin proteins, a typing approach should obviate the need to bioassay each newly described toxin and that predicts important biological characteristics.
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Updating benchtop sequencing performance comparison
Sebastian Jünemann,Sebastian Jünemann,Fritz J. Sedlazeck,Karola Prior,Andreas Albersmeier,Uwe John,Jörn Kalinowski,Alexander Mellmann,Alexander Goesmann,Arndt von Haeseler,Jens Stoye,Dag Harmsen +11 more
TL;DR: An up-to-date snapshot of how benchtop platforms have evolved since the previous study is provided to bring readers’ attention to some shortcomings in the report from Loman et al.1.
Journal ArticleDOI
Evaluation of Matrix-Assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry in Comparison to 16S rRNA Gene Sequencing for Species Identification of Nonfermenting Bacteria
Alexander Mellmann,Joann L. Cloud,Thomas Maier,Ursula Keckevoet,I. Ramminger,Peter C. Iwen,James J. Dunn,Gerri S. Hall,Deborah A. Wilson,P. LaSala,Markus Kostrzewa,Dag Harmsen +11 more
TL;DR: The use of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry for species identification of nonfermenting bacteria provided accurate and reproducible results within 10 min without any substantial costs for consumables.