Sukhyun Song

TL;DR: It is determined that SC, which originates from blood vessels during the postnatal period, acquires lymphatic identity through upregulation of prospero homeobox protein 1 (PROX1), the master regulator of lymphatic development.

TL;DR: It is demonstrated that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also indispensable for maintaining SC integrity during adulthood, and the impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 agonists could be a therapeutic option for glaucoma.

TL;DR: It is demonstrated that the Notch pathway restricts sprouting angiogenesis by reducing the expression of proangiogenic regulator Sox17 at the post-transcriptional level.

TL;DR: It is demonstrated that Sox17 deficiency in mouse can induce IA under hypertensive conditions, suggesting Sox 17 deficiency as a potential genetic factor for IA formation, and the Sox17-deficient mouse model provides a novel platform to develop therapeutics for incurable IA.

TL;DR: It is shown that inhibition of the mitochondrial permeability transition pore (mPTP) by Cyclosporin A (CsA) promotes cardiomyocyte differentiation from PSCs and alters mitochondrial oxidative metabolism and redox signaling, which leads to differentiation of functionalCardiomyocytes from P SCs.