T
Taija Makinen
Researcher at Uppsala University
Publications - 108
Citations - 15436
Taija Makinen is an academic researcher from Uppsala University. The author has contributed to research in topics: Lymphatic system & Lymphangiogenesis. The author has an hindex of 53, co-authored 104 publications receiving 13658 citations. Previous affiliations of Taija Makinen include Max Planck Society & Cancer Research UK.
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Journal ArticleDOI
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
Marc G. Achen,Michael Jeltsch,Eola Kukk,Taija Makinen,Angela A. Vitali,Andrew F. Wilks,Kari Alitalo,Steven A. Stacker +7 more
TL;DR: A member of the VEGF family is identified by computer-based homology searching and it is demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other V EGF family members and that corresponds to the mature form of VEGf-C.
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Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
Yingdi Wang,Masanori Nakayama,Mara E. Pitulescu,Tim S. Schmidt,Magdalena L. Bochenek,Magdalena L. Bochenek,Akira Sakakibara,Susanne Adams,Susanne Adams,Alice Davy,Urban Deutsch,Urs Lüthi,Alcide Barberis,Laura E. Benjamin,Taija Makinen,Catherine D. Nobes,Ralf H. Adams,Ralf H. Adams +17 more
TL;DR: It is shown with genetic experiments in mouse and zebrafish that ephrin-B2, a transmembrane ligand for Eph receptor tyrosine kinases, promotes sprouting behaviour and motility in the angiogenic endothelium, and shows that full VEGFR3 signalling is coupled to receptor internalization.
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Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3
Taija Makinen,Tanja Veikkola,Satu Mustjoki,Terhi Karpanen,Bruno Catimel,Edouard C. Nice,Lyn M. Wise,Andrew A. Mercer,Heinrich Kowalski,Dontscho Kerjaschki,Steven A. Stacker,Marc G. Achen,Kari Alitalo +12 more
TL;DR: It is shown that VEGFR‐3 stimulation alone protects the lymphatic endothelial cells from serum deprivation‐induced apoptosis and induces their growth and migration, and defines the critical role of VEGF‐C/VEG FR‐3 signalling in the growth and survival of lymphatichelial cells.
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Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Taija Makinen,Lotta Jussila,Tanja Veikkola,Terhi Karpanen,Mikko I. Kettunen,Kalevi J. Pulkkanen,Risto A. Kauppinen,David A. Jackson,Hajime Kubo,Shin-Ichi Nishikawa,Seppo Ylä-Herttuala,Kari Alitalo +11 more
TL;DR: It is shown that a soluble form of VEGFR-3 is a potent inhibitor of Vascular endothelial growth factor (VEGF)-C and VEGF-D signaling, and when expressed in the skin of transgenic mice, it inhibits fetal lymphangiogenesis and induces a regression of already formed lymphatic vessels, though the blood vasculature remains normal.
Journal ArticleDOI
Signalling via vascular endothelial growth factor receptor‐3 is sufficient for lymphangiogenesis in transgenic mice
Tanja Veikkola,Lotta Jussila,Taija Makinen,Terhi Karpanen,Michael Jeltsch,Tatiana V. Petrova,Hajime Kubo,Gavin Thurston,Donald M. McDonald,Marc G. Achen,Steven A. Stacker,Kari Alitalo +11 more
TL;DR: It is demonstrated that stimulation of the VEGFR‐3 signal transduction pathway is sufficient to induce specifically lymphangiogenesis in vivo.