Sumana Kalyanasundaram

TL;DR: This work links two major theories on aging, DNA damage accumulation, and mitochondrial dysfunction through nuclear DNA damage-induced nuclear-mitochondrial signaling, and demonstrates that they are important pathophysiological determinants in premature aging of A-T, pointing to therapeutic interventions.

TL;DR: The study shows that real‐time PCR can be used to differentiate the two species in routine diagnostics and suggests the MinION portable sequencer is a simple and affordable approach which could be used by many laboratories.

TL;DR: A two-step MRSA screening algorithm with initial mec/nuc PCR followed by orfX-SCCmec PCR on positive samples was suggested and tested and allowed us to report MRSA results for 95.6% of all samples and 99 % of MRSA-negative samples after one day.

TL;DR: In this article , the potential beneficial effects of genetic and chemical interventions acting via mild iron instead of oxygen depletion was assessed, and it was shown that limiting iron availability in C. elegans through frataxin silencing or the iron chelator bipyridine, similar to hypoxia preconditioning, protects against hypoxiosis-, age-, and proteotoxicity-induced neuromuscular deficits.