M
Marya Morevati
Researcher at University of Copenhagen
Publications - 19
Citations - 909
Marya Morevati is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Circadian rhythm & Internal medicine. The author has an hindex of 9, co-authored 15 publications receiving 581 citations. Previous affiliations of Marya Morevati include National Institutes of Health.
Papers
More filters
Journal ArticleDOI
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Evandro Fei Fang,Henok Kassahun,Deborah L. Croteau,Morten Scheibye-Knudsen,Morten Scheibye-Knudsen,Krisztina Marosi,Huiming Lu,Raghavendra A. Shamanna,Sumana Kalyanasundaram,Sumana Kalyanasundaram,Ravi Chand Bollineni,Mark A. Wilson,Wendy B. Iser,Bradley N. Wollman,Marya Morevati,Marya Morevati,Jun Li,Jesse S. Kerr,Qiping Lu,Tyler B. Waltz,Jane Tian,David A. Sinclair,David A. Sinclair,Mark P. Mattson,Mark P. Mattson,Hilde Nilsen,Vilhelm A. Bohr,Vilhelm A. Bohr +27 more
TL;DR: This work links two major theories on aging, DNA damage accumulation, and mitochondrial dysfunction through nuclear DNA damage-induced nuclear-mitochondrial signaling, and demonstrates that they are important pathophysiological determinants in premature aging of A-T, pointing to therapeutic interventions.
Journal ArticleDOI
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.
Evandro Fei Fang,Yujun Hou,Sofie Lautrup,Martin Borch Jensen,Beimeng Yang,Tanima SenGupta,Domenica Caponio,Rojyar Khezri,Tyler G Demarest,Yahyah Aman,David M. Figueroa,Marya Morevati,Marya Morevati,Ho-Joon Lee,Hisaya Kato,Henok Kassahun,Henok Kassahun,Jong Hyuk Lee,Deborah Filippelli,Mustafa Nazir Okur,Aswin Mangerich,Deborah L. Croteau,Yoshiro Maezawa,Costas A. Lyssiotis,Tao Jun,Koutaro Yokote,Tor Erik Rusten,Tor Erik Rusten,Mark P. Mattson,Heinrich Jasper,Hilde Nilsen,Vilhelm A. Bohr,Vilhelm A. Bohr +32 more
TL;DR: The authors showed that NAD+ repletion restores NAD+ metabolic profiles and improves mitochondrial quality through DCT-1 and ULK-1-dependent mitophagy in Werner syndrome.
Journal ArticleDOI
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.
Evandro Fei Fang,Tyler B. Waltz,Henok Kassahun,Henok Kassahun,Qiping Lu,Jesse S. Kerr,Marya Morevati,Marya Morevati,Elayne M. Fivenson,Bradley N. Wollman,Krisztina Marosi,Mark A. Wilson,Wendy B. Iser,D. Mark Eckley,Yongqing Zhang,Elin Lehrmann,Ilya G. Goldberg,Morten Scheibye-Knudsen,Morten Scheibye-Knudsen,Mark P. Mattson,Hilde Nilsen,Vilhelm A. Bohr,Vilhelm A. Bohr,Kevin G. Becker +23 more
TL;DR: Tomatidine extends lifespan and healthspan in C. elegans, an animal model of aging which shares many major longevity pathways with mammals, and points to new approaches for pharmacological interventions for diseases of aging.
Journal ArticleDOI
Lamin A/C promotes DNA base excision repair.
Scott Maynard,Guido Keijzers,Mansour Akbari,Michael Ben Ezra,Arnaldur Hall,Marya Morevati,Morten Scheibye-Knudsen,Susana Gonzalo,Jiri Bartek,Vilhelm A. Bohr,Vilhelm A. Bohr +10 more
TL;DR: The results provide novel insights into the functional interplay between the nuclear lamina and cellular defenses against oxidative DNA damage, with implications for cancer and aging.
Journal ArticleDOI
Sarcopenia, Aging and Prospective Interventional Strategies.
Tyler B. Waltz,Elayne M. Fivenson,Marya Morevati,Chuanhao Li,Kevin G. Becker,Vilhelm A. Bohr,Evandro Fei Fang +6 more
TL;DR: Assessment of naturally-occurring compounds derived from commonly consumed foods that possess anti-sarcopenic effects should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.