R
Raghavendra A. Shamanna
Researcher at National Institutes of Health
Publications - 19
Citations - 1095
Raghavendra A. Shamanna is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA repair & Homologous recombination. The author has an hindex of 13, co-authored 17 publications receiving 835 citations. Previous affiliations of Raghavendra A. Shamanna include University of Copenhagen & Rutgers University.
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Journal ArticleDOI
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Evandro Fei Fang,Henok Kassahun,Deborah L. Croteau,Morten Scheibye-Knudsen,Morten Scheibye-Knudsen,Krisztina Marosi,Huiming Lu,Raghavendra A. Shamanna,Sumana Kalyanasundaram,Sumana Kalyanasundaram,Ravi Chand Bollineni,Mark A. Wilson,Wendy B. Iser,Bradley N. Wollman,Marya Morevati,Marya Morevati,Jun Li,Jesse S. Kerr,Qiping Lu,Tyler B. Waltz,Jane Tian,David A. Sinclair,David A. Sinclair,Mark P. Mattson,Mark P. Mattson,Hilde Nilsen,Vilhelm A. Bohr,Vilhelm A. Bohr +27 more
TL;DR: This work links two major theories on aging, DNA damage accumulation, and mitochondrial dysfunction through nuclear DNA damage-induced nuclear-mitochondrial signaling, and demonstrates that they are important pathophysiological determinants in premature aging of A-T, pointing to therapeutic interventions.
Journal ArticleDOI
WRN regulates pathway choice between classical and alternative non-homologous end joining
Raghavendra A. Shamanna,Huiming Lu,Jessica K De Freitas,Jane Tian,Deborah L. Croteau,Vilhelm A. Bohr +5 more
TL;DR: It is reported that WRN regulates the pathway choice between classical (c)- and alternative (alt)-nonhomologous end joining (NHEJ) during DNA double-strand break (DSB) repair and shields DSBs from MRE11/CtIP-mediated resection to prevent large deletions and telomere fusions.
Journal ArticleDOI
RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks
Huiming Lu,Raghavendra A. Shamanna,Guido Keijzers,Roopesh Anand,Lene Juel Rasmussen,Petr Cejka,Deborah L. Croteau,Vilhelm A. Bohr,Vilhelm A. Bohr +8 more
TL;DR: It is reported that RECQL4 is an important participant in HR-dependent DSBR, which is the initial and an essential step of homologous recombination (HR)-dependent DNA double-strand break repair (DSBR).
Journal ArticleDOI
Loss of ARID1A in tumor cells renders selective vulnerability to combined ionizing radiation and PARP inhibitor therapy
Youngran Park,M. Herman Chui,Yohan Suryo Rahmanto,Zheng Cheng Yu,Raghavendra A. Shamanna,Marina A. Bellani,Stephanie Gaillard,Ayse Ayhan,Ayse Ayhan,Akila N. Viswanathan,Michael M. Seidman,Sonia Franco,Anthony K.L. Leung,Anthony K.L. Leung,Vilhelm A. Bohr,Ie Ming Shih,Tian Li Wang +16 more
TL;DR: The results show that ARID1A is essential for establishing an open chromatin state upon DNA damage, a process required for recruitment of 53BP1 and RIF1, key mediators of non-homologous end-joining (NHEJ) machinery, to DNA lesions, and suggest a novel biologically informed strategy for treating ARid1A-deficient malignancies.
Journal ArticleDOI
The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining.
Raghavendra A. Shamanna,Mainul Hoque,Anita Lewis-Antes,Edouard I. Azzam,Edouard I. Azzam,David Lagunoff,Tsafi Pe'ery,Michael B. Mathews,Michael B. Mathews +8 more
TL;DR: The results identify the NF90/NF45 complex as a regulator of DNA damage repair mediated by DNA-PK and suggest that structured RNA may modulate this process.