K
Kunihiro Matsumoto
Researcher at Nagoya University
Publications - 241
Citations - 35618
Kunihiro Matsumoto is an academic researcher from Nagoya University. The author has contributed to research in topics: MAP kinase kinase kinase & Signal transduction. The author has an hindex of 98, co-authored 237 publications receiving 33946 citations. Previous affiliations of Kunihiro Matsumoto include Kyoto University.
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Journal ArticleDOI
Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways
Hidenori Ichijo,Eisuke Nishida,Kenji Irie,Peter ten Dijke,Masao Saitoh,Tetsuo Moriguchi,Minoru Takagi,Kunihiro Matsumoto,Kohei Miyazono,Yukiko Gotoh +9 more
TL;DR: Overexpression of ASK1 induced apoptotic cell death, andASK1 was activated in cells treated with tumor necrosis factor-α, and TNF-α-induced apoptosis was inhibited by a catalytically inactive form of AsK1.
Journal ArticleDOI
Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction
Kyoko Yamaguchi,Kyoko Shirakabe,Hiroshi Shibuya,Kenji Irie,Isao Oishi,Naoto Ueno,Tadatsugu Taniguchi,Eisuke Nishida,Kunihiro Matsumoto +8 more
TL;DR: Results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-β superfamily members.
Journal ArticleDOI
Spatiotemporal rescue of memory dysfunction in Drosophila
TL;DR: A method for temporal and regional gene expression targeting in Drosophila is developed and shown the simultaneous spatial and temporal rescue of a memory defect, which rules out a developmental brain defect in the etiology of this deficit.
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The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
Jun Ninomiya-Tsuji,Kazuya Kishimoto,Atsushi Hiyama,Jun-ichiro Inoue,Zhaodan Cao,Kunihiro Matsumoto +5 more
TL;DR: It is shown that the MAPKK kinase TAK1 acts upstream of NIK in the IL-1-activated signalling pathway and that TAK 1 associates with TRAF6 during IL- 1 signalling, which indicates that Taker1 links TRAf6 to the NIK–IKK cascade in theIL-1 signalling pathway.
Journal ArticleDOI
Essential function for the kinase TAK1 in innate and adaptive immune responses.
Shintaro Sato,Hideki Sanjo,Kiyoshi Takeda,Jun Ninomiya-Tsuji,Masahiro Yamamoto,Taro Kawai,Kunihiro Matsumoto,Osamu Takeuchi,Shizuo Akira +8 more
TL;DR: It is shown that TAK1 is key in the cellular response to a variety of stimuli and was indispensable for cellular responses to Toll-like receptor ligands, CD40 and B cell receptor crosslinking.