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Sumon Datta
Researcher at Howard Hughes Medical Institute
Publications - Â 5
Citations - Â 2055
Sumon Datta is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 4, co-authored 5 publications receiving 1923 citations. Previous affiliations of Sumon Datta include Harvard University & Boston Children's Hospital.
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Journal ArticleDOI
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
Sabine Loewer,Moran N. Cabili,Moran N. Cabili,Mitchell Guttman,Yuin-Han Loh,Kelly Thomas,Kelly Thomas,In-Hyun Park,Manuel Garber,Matthew Curran,Tamer T. Onder,Suneet Agarwal,Philip D. Manos,Philip D. Manos,Sumon Datta,Sumon Datta,Eric S. Lander,Eric S. Lander,Thorsten M. Schlaeger,Thorsten M. Schlaeger,George Q. Daley,John L. Rinn,John L. Rinn +22 more
TL;DR: In this paper, the authors characterized the transcriptional reorganization of large intergenic non-coding RNAs (lincRNAs) that occurs upon derivation of human iPSCs and identified numerous lincRNA whose expression is linked to pluripotency.
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
Sabine Loewer,Moran N. Cabili,Moran N. Cabili,Mitchell Guttman,Yuin-Han Loh,Kelly Thomas,Kelly Thomas,In-Hyun Park,Manuel Garber,Matthew Curran,Tamer T. Onder,Suneet Agarwal,Philip D. Manos,Philip D. Manos,Sumon Datta,Sumon Datta,Eric S. Lander,Eric S. Lander,Thorsten M. Schlaeger,Thorsten M. Schlaeger,George Q. Daley,John L. Rinn,John L. Rinn +22 more
TL;DR: It is found that one such lincRNA (lincRNA-RoR) modulates reprogramming, thus providing a first demonstration for critical functions of lincRNAs in the derivation of pluripotent stem cells.
Journal ArticleDOI
DHODH modulates transcriptional elongation in the neural crest and melanoma
Richard M. White,Jennifer N. Cech,Sutheera Ratanasirintrawoot,Charles P. Lin,Peter B. Rahl,Christopher J. Burke,Erin M. Langdon,Matthew L. Tomlinson,Jack T. Mosher,Charles K. Kaufman,Charles K. Kaufman,Frank Chen,Hannah K. Long,Martin Kramer,Sumon Datta,Donna Neuberg,Scott R. Granter,Richard A. Young,Sean J. Morrison,Grant N. Wheeler,Leonard I. Zon +20 more
TL;DR: Developmental pathways in neural crest cells that have a direct bearing on melanoma formation are highlighted.
Journal ArticleDOI
Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.
Il Ho Jang,Yi Fen Lu,Long Zhao,Pamela L. Wenzel,Tsutomu Kume,Sumon Datta,Natasha Arora,Jordi Guiu,Mounia Lagha,Peter Geon Kim,Eun Kyoung Do,Jae Ho Kim,Thorsten M. Schlaeger,Thorsten M. Schlaeger,Leonard I. Zon,Leonard I. Zon,Anna Bigas,Caroline E. Burns,George Q. Daley +18 more
TL;DR: It is discovered that Notch induction enhances hematopoietic potential and promotes the specification of hemogenic endothelium in differentiating cultures of mouse embryonic stem cells, and Foxc2 is identified as a highly upregulated transcript in the hemogen endothelial population.
DHODH modulates transcriptional elongation in the neural crest and melanoma
Richard M. White,Jennifer N. Cech,Sutheera Ratanasirintrawoot,Charles P. Lin,Peter B. Rahl,Christopher J. Burke,Erin M. Langdon,Matthew L. Tomlinson,Jack T. Mosher,Charles K. Kaufman,Charles K. Kaufman,Frank Chen,Hannah K. Long,Martin Kramer,Sumon Datta,Donna Neuberg,Scott R. Granter,Richard A. Young,Sean J. Morrison,Grant N. Wheeler,Leonard I. Zon +20 more
TL;DR: This paper used zebrafish embryos to identify the initiating transcriptional events that occur on activation of human BRAF(V600E), which encodes an amino acid substitution mutant of BRAF in the neural crest lineage.