M
Matthew L. Tomlinson
Researcher at University of East Anglia
Publications - 17
Citations - 1433
Matthew L. Tomlinson is an academic researcher from University of East Anglia. The author has contributed to research in topics: Xenopus & Neural crest. The author has an hindex of 12, co-authored 16 publications receiving 1309 citations. Previous affiliations of Matthew L. Tomlinson include John Innes Centre & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
DHODH modulates transcriptional elongation in the neural crest and melanoma
Richard M. White,Jennifer N. Cech,Sutheera Ratanasirintrawoot,Charles P. Lin,Peter B. Rahl,Christopher J. Burke,Erin M. Langdon,Matthew L. Tomlinson,Jack T. Mosher,Charles K. Kaufman,Charles K. Kaufman,Frank Chen,Hannah K. Long,Martin Kramer,Sumon Datta,Donna Neuberg,Scott R. Granter,Richard A. Young,Sean J. Morrison,Grant N. Wheeler,Leonard I. Zon +20 more
TL;DR: Developmental pathways in neural crest cells that have a direct bearing on melanoma formation are highlighted.
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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
Daniele Bergamaschi,Yardena Samuels,Nigel J. O'Neil,Giuseppe Trigiante,Tim Crook,Jung-Kuang Hsieh,Daniel J. O'Connor,Shan Zhong,Isabelle Campargue,Matthew L. Tomlinson,Patricia E. Kuwabara,Xin Lu +11 more
TL;DR: iASPP is an evolutionarily conserved inhibitor of p53; inhibition of iASPP by RNA-mediated interference or antisense RNA in C. elegans or human cells, respectively, induces p53-dependent apoptosis and could provide an important new strategy for treating tumors expressing wild-type p53.
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High‐throughput protein localization in Arabidopsis using Agrobacterium‐mediated transient expression of GFP‐ORF fusions
TL;DR: A streamlined and systematic method for cloning green fluorescent protein (GFP)-open reading frame (ORF) fusions and assessing their subcellular localization in Arabidopsis thaliana cells is described, which allows the economical handling of hundreds of expressed plant proteins in a timely fashion.
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CycD1, a Putative G1 Cyclin from Antirrhinum majus, Accelerates the Cell Cycle in Cultured Tobacco BY-2 Cells by Enhancing Both G1/S Entry and Progression through S and G2 Phases
Olga A. Koroleva,Matthew L. Tomlinson,Piyarat Parinyapong,Lali Sakvarelidze,David J. Leader,Peter Shaw,John H. Doonan +6 more
TL;DR: D cyclin function may have diverged between plants and animals, as CycD1 can promote both G0/G1/S and S/G2/M progression, in contrast with animal D cyclins.
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A Chemical Genomic Approach Identifies Matrix Metalloproteinases as Playing an Essential and Specific Role in Xenopus Melanophore Migration
Matthew L. Tomlinson,Pingping Guan,Richard J. Morris,Mark Fidock,Martin Rejzek,Carla Garcia-Morales,Robert A. Field,Grant N. Wheeler +7 more
TL;DR: Morpholino-mediated knockdown of both MMPs demonstrates they play a key role in melanophore migration and partially phenocopy the effect of NSC 84093, identified as affecting melanophores in the developing embryo.