S
Sunil K. Chauhan
Researcher at Massachusetts Eye and Ear Infirmary
Publications - 141
Citations - 6890
Sunil K. Chauhan is an academic researcher from Massachusetts Eye and Ear Infirmary. The author has contributed to research in topics: Transplantation & Cornea. The author has an hindex of 40, co-authored 126 publications receiving 5268 citations. Previous affiliations of Sunil K. Chauhan include Harvard University & Sanjay Gandhi Post Graduate Institute of Medical Sciences.
Papers
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Journal ArticleDOI
TFOS DEWS II pathophysiology report
Anthony J. Bron,Anthony J. Bron,Cintia S. de Paiva,Sunil K. Chauhan,Stefano Bonini,Eric E. Gabison,Sandeep Jain,Erich Knop,Maria Markoulli,Yoko Ogawa,Victor L. Perez,Yuichi Uchino,Norihiko Yokoi,Driss Zoukhri,David A. Sullivan +14 more
TL;DR: The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms involved in the initiation and perpetuation of dry eye disease, finding the targeting of the terminal duct in meibomian gland disease and the influence of gaze dynamics and the closed eye state on tear stability and ocular surface inflammation to be important.
Journal ArticleDOI
Dry eye disease: an immune-mediated ocular surface disorder.
TL;DR: The fundamental links between inflammation and dry eye disease are reviewed and the clinical implications of inflammation in disease management are discussed and the self-perpetuating inflammatory cycle is discussed.
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TFOS DEWS II Report Executive Summary
Jennifer P. Craig,J. Daniel Nelson,J. Daniel Nelson,Dimitri T. Azar,Carlos Belmonte,Anthony J. Bron,Anthony J. Bron,Sunil K. Chauhan,Cintia S. de Paiva,José Álvaro Pereira Gomes,Katherine M. Hammitt,Lyndon Jones,Jason J. Nichols,Kelly K. Nichols,Gary D. Novack,Gary D. Novack,Fiona Stapleton,Mark D. P. Willcox,James S. Wolffsohn,David A. Sullivan +19 more
TL;DR: This article presents an Executive Summary of the conclusions and recommendations of the 10-chapter TFOS DEWS II report.
Journal ArticleDOI
Autoimmunity in Dry Eye Is Due to Resistance of Th17 to Treg Suppression
Sunil K. Chauhan,Jaafar El Annan,Tatiana Ecoiffier,Sunali Goyal,Qiang Zhang,Daniel R. Saban,Reza Dana +6 more
TL;DR: In vivo blockade of IL-17 significantly reduces the severity and progression of disease, which is paralleled by a reduction in the expansion of Th17 cells and restoration of Treg function, and suggest a new target for dry eye therapy.
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Levels of Foxp3 in Regulatory T Cells Reflect Their Functional Status in Transplantation
TL;DR: It is shown that far more relevant than Treg frequency is their level of Foxp3 expression, which is directly associated with the potential of Tregs to prevent allograft rejection by producing regulatory cytokines and suppressing effector T cell activation.