Jennifer S. Isaacs

TL;DR: In this article, a novel fumarate-dependent pathway for regulating HPH activity and HIF protein levels was proposed, which coincides with FH inhibition and upregulation of HIF upregulation.

TL;DR: It is demonstrated that IL‐1β up‐regulates functional HIF‐1α protein through a classical inflammatory signaling pathway involving NFkB and COX‐2, culminating in up‐regulation of VEGF, a potent angiogenic factor required for tumor growth and metastasis.

TL;DR: It is demonstrated that disruption of Hsp90 function promotes Hif-1α degradation via a novel, oxygen-independent E3 ubiquitin ligase and diminishes HIF-1 α transcriptional activity, thus extending the utility of these drugs as therapeutic anticancer agents.

TL;DR: It is apparent that Hsp90 inhibitors are unique in that, although they are directed toward a specific molecular target, they simultaneously inhibit multiple signaling pathways on which cancer cells depend for growth and survival, thereby perhaps circumventing the characteristic genetic plasticity of cancer cells.

TL;DR: The gene for a new form of hereditary RCC associated with cutaneous tumors, lung cysts, and colon polyps or cancer has recently been identified and the HLRC gene has been found to be the Krebs cycle enzyme, fumarate hydratase.