S
Supipi Kaluarachchi
Researcher at University of Toronto
Publications - 3
Citations - 318
Supipi Kaluarachchi is an academic researcher from University of Toronto. The author has contributed to research in topics: Kinase & Cell cycle. The author has an hindex of 3, co-authored 3 publications receiving 292 citations.
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Journal ArticleDOI
Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression.
Christoph F. Kurat,Heimo Wolinski,Julia Petschnigg,Supipi Kaluarachchi,Brenda J. Andrews,Klaus Natter,Sepp D. Kohlwein +6 more
TL;DR: In this paper, the major yeast TG lipase Tgl4, the functional ortholog of the murine adipose Tgl lipase ATGL, is phosphorylated and activated by cyclin-dependent kinase 1 (Cdk1/Cdc28) for early bud formation in late G1 phase of the cell cycle.
Journal ArticleDOI
Dual Regulation by Pairs of Cyclin-Dependent Protein Kinases and Histone Deacetylases Controls G1 Transcription in Budding Yeast
Dongqing Huang,Supipi Kaluarachchi,Dewald van Dyk,Helena Friesen,Richelle Sopko,Wei Ye,Nazareth Bastajian,Jason Moffat,Holly E. Sassi,Michael Costanzo,Brenda J. Andrews +10 more
TL;DR: Initiation of the cell division cycle in yeast is controlled by two distinct kinases that coordinately regulate the interaction of Whi5, a repressor of initiation, with histone deacetylases.
Journal ArticleDOI
Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein
Christoph F. Kurat,Jean-Philippe Lambert,Dewald van Dyk,Kyle Tsui,Harm van Bakel,Supipi Kaluarachchi,Helena Friesen,Pinay Kainth,Corey Nislow,Daniel Figeys,Jeffrey Fillingham,Brenda J. Andrews +11 more
TL;DR: This study demonstrates that S-phase transcription of the model histone gene HTA1 in yeast is regulated by a novel attach-release mechanism involving phosphorylation of the conserved chromatin boundary protein Yta7 by both cyclin-dependent kinase 1 (Cdk1) and casein kinase 2 (CK2).