Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression.
Christoph F. Kurat,Heimo Wolinski,Julia Petschnigg,Supipi Kaluarachchi,Brenda J. Andrews,Klaus Natter,Sepp D. Kohlwein +6 more
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TLDR
In this paper, the major yeast TG lipase Tgl4, the functional ortholog of the murine adipose Tgl lipase ATGL, is phosphorylated and activated by cyclin-dependent kinase 1 (Cdk1/Cdc28) for early bud formation in late G1 phase of the cell cycle.About:
This article is published in Molecular Cell.The article was published on 2009-01-16 and is currently open access. It has received 220 citations till now. The article focuses on the topics: Cyclin-dependent kinase 1 & Lipolysis.read more
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Lipid Droplets and Cellular Lipid Metabolism
TL;DR: The current knowledge of LD cell biology and its translation to physiology is reviewed, finding that many aspects of LD biology are unknown.
Journal ArticleDOI
FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling
Rudolf Zechner,Robert Zimmermann,Thomas O. Eichmann,Sepp D. Kohlwein,Guenter Haemmerle,Achim Lass,Frank Madeo +6 more
TL;DR: New findings that lipolytic products and intermediates participate in cellular signaling processes and that “lipolytic signaling” is particularly important in many nonadipose tissues unveil a previously underappreciated aspect of lipolysis, which may be relevant for human disease.
Journal ArticleDOI
Lipid Droplets Finally Get a Little R-E-S-P-E-C-T
TL;DR: Long underappreciated as important cellular organelles, lipid droplets are finally being recognized as dynamic structures with a complex and interesting biology.
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Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets
Florian Wilfling,Huajin Wang,Joel T. Haas,Natalie Krahmer,Travis J. Gould,Aki Uchida,Ji-Xin Cheng,Morven Graham,Romain Christiano,Florian Fröhlich,Xinran Liu,Kimberly K. Buhman,Rosalind A. Coleman,Joerg Bewersdorf,Robert V. Farese,Tobias C. Walther +15 more
TL;DR: The results explain how TG synthesis is coupled with LD growth and identify two distinct LD subpopulations based on their capacity for localized TG synthesis.
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Lipid Droplet Biogenesis.
TL;DR: A model of LD formation from the ER in distinct steps is presented and the biology of proteins that govern this biophysical process are highlighted, as are connections with physiology and diseases linked to alterations in LD biology.
References
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TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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Obesity and the Regulation of Energy Balance
TL;DR: The last 5 years of the millennium have witnessed a dramatic increase in understanding of the biology of regulated energy balance and body weight, and insights from the sequencing of the human genome and the coming advances in proteomics are likely to fuel the next wave of progress.
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Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Robert Zimmermann,Juliane G. Strauss,Guenter Haemmerle,Gabriele Schoiswohl,Ruth Birner-Gruenberger,Monika Riederer,Achim Lass,Georg Neuberger,Frank Eisenhaber,Albin Hermetter,Rudolf Zechner +10 more
TL;DR: It is reported that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis, and it is interesting that ATGL contains a “patatin domain” common to plant acyl-hydrolases.
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Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Laura L. Listenberger,Xianlin Han,Sarah Lewis,Sylvaine Cases,Robert V. Farese,Daniel S. Ory,Jean E. Schaffer +6 more
TL;DR: This work demonstrates in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of these lipids to distinct cellular metabolic fates, and supports a model of cellular lipid metabolism in which unsaturated fatty acids serve a protective function against lipotoxicity though promotion of triglyceride accumulation.
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The function of cytidine coenzymes in the biosynthesis of phospholipides.
TL;DR: The ratio of P32 to Cl4 in the product was closely similar to that of the labeled P-choline, suggesting incorporation of both phosphorus and choline as an intact unit into a phospholipide, presumably lecithin.