S
Susan D. Brain
Researcher at King's College London
Publications - 226
Citations - 14656
Susan D. Brain is an academic researcher from King's College London. The author has contributed to research in topics: Calcitonin gene-related peptide & Receptor. The author has an hindex of 55, co-authored 220 publications receiving 13539 citations. Previous affiliations of Susan D. Brain include British Heart Foundation & Royal College of Surgeons of England.
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Journal ArticleDOI
Calcitonin gene-related peptide is a potent vasodilator
TL;DR: It is suggested that local extravascular release of CGRP may be involved in the physiological control of blood flow and that circulating C GRP may contribute to hyperaemia in certain pathological conditions.
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Resolution of inflammation: state of the art, definitions and terms.
Charles N. Serhan,Susan D. Brain,Christopher D. Buckley,Derek W. Gilroy,Christopher Haslett,Luke A. J. O'Neill,Mauro Perretti,Adriano G. Rossi,John L. Wallace +8 more
TL;DR: A consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti‐inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today.
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Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
TL;DR: It is concluded that CGRP is an important peptide in mammalian biology, but it is too early at present to know if new medicines for disease treatment will emerge from knowledge concerning this molecule.
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Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin
Susan D. Brain,Andrew D. Grant +1 more
TL;DR: The receptor-mediated vascular activities of calcitonin gene-related peptide (CGRP) and the structurally related peptide adrenomedullin are summarized, and potential therapeutic applications based on use of antagonists and gene targeting of agonists are discussed.
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Neutrophils in development of multiple organ failure in sepsis
TL;DR: It is proposed that an inappropriate activation and positioning of neutrophils within the microvasculature contributes to the pathological manifestations of multiple organ failure and it is suggested that targeting neutrophil and their interactions with blood vessel walls could be a worthwhile therapeutic strategy for sepsis.