Susan Heggie

TL;DR: Hypermetabolic patients with ALS have a greater level of lower motor neuron involvement, faster rate of functional decline and shorter survival, and the metabolic index could be important for informing prognosis in ALS.

TL;DR: Findings support limb dominance as a significant factor underlying onset and spread of ALS, with UMN processes playing an important role.

TL;DR: It is demonstrated that patients with amyotrophic lateral sclerosis with distinct clinical features have differential myeloid cell signatures, and Identified cell populations and markers may be candidates for targeted mechanistic studies and immunomodulation therapies in amyotroph lateral sclerosis.

TL;DR: Gene discovery has provided remarkable biological insights into amyotrophic lateral sclerosis and one challenge for clinical application of genetic testing is critical evaluation of the significance of reported variants.

TL;DR: In this paper , the authors report that muscle from motor neuron disease (MND) patients have an increased proportion of slow fibers and muscle fibers with smaller diameter than non-MND.