M
Matthew R. Robinson
Researcher at Institute of Science and Technology Austria
Publications - 114
Citations - 10926
Matthew R. Robinson is an academic researcher from Institute of Science and Technology Austria. The author has contributed to research in topics: Population & Genetic architecture. The author has an hindex of 41, co-authored 110 publications receiving 7698 citations. Previous affiliations of Matthew R. Robinson include University of Sheffield & University of Melbourne.
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Journal ArticleDOI
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
James J. Lee,Robbee Wedow,Aysu Okbay,Edward Kong,Omeed Maghzian,Meghan Zacher,Tuan Anh Nguyen-Viet,Peter Bowers,Julia Sidorenko,Julia Sidorenko,Richard Karlsson Linnér,Richard Karlsson Linnér,Mark Alan Fontana,Mark Alan Fontana,Tushar Kundu,Chanwook Lee,Hui Li,Ruoxi Li,Rebecca Royer,Pascal Timshel,Pascal Timshel,Raymond K. Walters,Raymond K. Walters,Emily A. Willoughby,Loic Yengo,Maris Alver,Yanchun Bao,David W. Clark,Felix R. Day,Nicholas A. Furlotte,Peter K. Joshi,Peter K. Joshi,Kathryn E. Kemper,Aaron Kleinman,Claudia Langenberg,Reedik Mägi,Joey W. Trampush,Shefali S. Verma,Yang Wu,Max Lam,Jing Hua Zhao,Zhili Zheng,Zhili Zheng,Jason D. Boardman,Harry Campbell,Jeremy Freese,Kathleen Mullan Harris,Caroline Hayward,Pamela Herd,Pamela Herd,Meena Kumari,Todd Lencz,Todd Lencz,Jian'an Luan,Anil K. Malhotra,Anil K. Malhotra,Andres Metspalu,Lili Milani,Ken K. Ong,John R. B. Perry,David J. Porteous,Marylyn D. Ritchie,Melissa C. Smart,Blair H. Smith,Joyce Y. Tung,Nicholas J. Wareham,James F. Wilson,Jonathan P. Beauchamp,Dalton Conley,Tõnu Esko,Steven F. Lehrer,Steven F. Lehrer,Steven F. Lehrer,Patrik K. E. Magnusson,Sven Oskarsson,Tune H. Pers,Tune H. Pers,Matthew R. Robinson,Matthew R. Robinson,Kevin Thom,Chelsea Watson,Christopher F. Chabris,Michelle N. Meyer,David Laibson,Jian Yang,Magnus Johannesson,Philipp Koellinger,Philipp Koellinger,Patrick Turley,Patrick Turley,Peter M. Visscher,Daniel J. Benjamin,Daniel J. Benjamin,David Cesarini,David Cesarini +94 more
TL;DR: A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance ineducational attainment and 7–10% ofthe variance in cognitive performance, which substantially increases the utility ofpolygenic scores as tools in research.
Journal ArticleDOI
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
Zhihong Zhu,Futao Zhang,Han Hu,Andrew Bakshi,Matthew R. Robinson,Joseph E. Powell,Grant W. Montgomery,Michael E. Goddard,Naomi R. Wray,Peter M. Visscher,Jian Yang +10 more
TL;DR: A method is proposed that integrates summary-level data from GWAS with data from expression quantitative trait locus (eQTL) studies to identify genes whose expression levels are associated with a complex trait because of pleiotropy, and prioritize 126 genes that provide important leads to design future functional studies.
Journal ArticleDOI
Genetic mechanisms of critical illness in Covid-19.
Erola Pairo-Castineira,Erola Pairo-Castineira,Sara Clohisey,Lucija Klaric,Andrew D. Bretherick,Konrad Rawlik,Dorota Pasko,Susan P. Walker,Nicholas J. Parkinson,Max Head Fourman,Clark D Russell,James J Furniss,Anne Richmond,E. Gountouna,Nicola Wrobel,David A Harrison,B. Wang,Yang Wu,A. Meynert,Fiona Griffiths,Wilna Oosthuyzen,Athanasios Kousathanas,Loukas Moutsianas,Z. Yang,R. Zhai,Canbin Zheng,Graeme R. Grimes,Rupert Beale,Jonathan E Millar,Barbara Shih,Seán Keating,Marie Zechner,Chris Haley,David J. Porteous,Caroline Hayward,Jian Yang,Julian C. Knight,Charlotte Summers,Manu Shankar-Hari,Manu Shankar-Hari,Paul Klenerman,Lance Turtle,Antonia Ho,S. C. Moore,Charles J. Hinds,P. Horby,Alistair Nichol,Alistair Nichol,Alistair Nichol,David M. Maslove,Lowell Ling,Daniel F. McAuley,Hugh Montgomery,Timothy S. Walsh,Alexandre C. Pereira,Alessandra Renieri,C. Ponting,J. Meikle,P. Finernan,E. Mcmaster,E. Mcmaster,Andy Law,J. K. Baillie,T. Paterson,T. Wackett,Robert C. Armstrong,Robert C. Armstrong,R. Clark,A. Coutts,L. Donnelly,Tamara Gilchrist,K. Hafezi,K. Hafezi,L. Macgillivray,L. Macgillivray,Alan MacLean,Sarah McCafferty,Kirstie Morrice,J. Weaver,C. Boz,C. Boz,A. Golightly,Minghong Ward,H. Mal,H. Szoor-McElhinney,Anthony Brown,Ross Hendry,A. Stenhouse,L. Cullum,D. Law,S. Law,R. Law,Maaike C. Swets,N. Day,F. Taneski,Emma L. Duncan,David Collier,S. Wood,A. Zak,C. Borra,M. Matharu,P. May,Z. Alldis,O. Mitchelmore,R. Bowles,A. Easthope,F. Bibi,I. Lancoma-Malcolm,J. Gurasashvili,J. Pheby,J. Shiel,M. Bolton,Minal Patel,M. Taylor,O. Zongo,P. Ebano,P. Harding,R. Astin-Chamberlain,Y. Choudhury,Anna Cox,D. Kallon,M. Burton,R. Hall,S. Blowes,Z. Prime,J. Biddle,O. Prysyazhna,T. Newman,C. Tierney,J. Kassam,Marlies Ostermann,S. Campos,A. Bociek,R. Lim,N. Grau,T. O. Jones,C. Whitton,M. Marotti,Gill Arbane,S. Bonner,K. Hugill,J. Reid,Ingeborg Welters,V. Waugh,Katherine Williams,D. Shaw,J. F. Roman,M. L. Martinez,Elizabeth M. Johnson,A. Waite,B. Johnston,D. Hamilton,S. Mulla,Mark J. W. McPhail,John A. S. Smith,L. Barclay,D. Hope,Corrienne McCulloch,L. McQuillan,S. Clark,J. Singleton,K. Priestley,N. Rea,M. Callaghan,R. Campbell,G. Andrew,L. Marshall,Stuart McKechnie,P. Hutton,A. Bashyal,N. Davidson,P. Polgarova,K. Stroud,N. Pathan,K. Elston,Sutapa Agrawal,Ceri Battle,L. Newey,Tim Rees,R. Harford,E. Brinkworth,Martin S. Williams,C. Murphy,I. M. S. White,M. Croft,N. Bandla,M. Gellamucho,J. Tomlinson,H. Turner,Michael Davies,A. Quinn,I. Hussain,Christopher C. Thompson,H. Parker,R. Bradley,R. Griffiths,J. Scriven,A. Nilsson,Matthew G.D. Bates,J. Dasgin,Janusz Gill,Alex Puxty,S. Cathcart,D. Salutous,L. Turner,K. Duffy,K. Puxty,Anna Maria Joseph,R. Herdman-Grant,R. Simms,A. Swain,A. Naranjo,R. Crowe,K. Sollesta,A. Loveridge,D. Baptista,E. Morino,M. Davey,D. Golden,J. Jones,J. Moreno Cuesta,A. Haldeos,D. Bakthavatsalam,Royce P Vincent,M. Elhassan,K. Xavier,Anand K. Ganesan,D. Purohit,M. Abdelrazik,J.M. Morgan,L. Akeroyd,S. Bano,T. Lawton,D. Warren,M. Bromley,K. Sellick,L. Gurr,B. Wilkinson,V. Nagarajan,P. Szedlak,Jason Cupitt,E. Stoddard,L. Benham,S. Preston,Shondipon Laha,N. Slawson,Z. Bradshaw,Jamie Brown,M. Caswell,S. Melling,P. Bamford,M. Faulkner,K. Cawley,H. Jeffrey,E. London,H. Sainsbury,I. Nagra,F. Nasir,C. Dunmore,R. L. Jones,A. Abraheem,M. Al-Moasseb,R. Girach,G. Padden,Josephine M. Egan,C. Brantwood,P. Alexander,J. Bradley-Potts,Susan Allen,Timothy Felton,S. Manna,S. Farnell-Ward,S. Leaver,J. Queiroz,E. Maccacari,D. Dawson,C. C. Delgado,R. P. Saluzzio,O. Ezeobu,L. Ding,C. Sicat,R. Kanu,G. Durrant,J. Texeira,Abby Harrison,T. Samakomva,H. Willis,B. Hopkins,L. Thrasyvoulou,M. Jackson,A. Zaki,C. Tibke,Suzanne Bennett,W. Woodyatt,A. Kent,E. Goodwin,C. Brandwood,Lee B. Smith,Kevin Rooney,Neil C. Thomson,N. Rodden,Ellen C Hughes,D. McGlynn,C. Clark,P. Clark,Laurent Abel,R. Sundaram,L. Gemmell,M. Brett,J. Hornsby,P. MacGoey,R. Price,B. Digby,P. O'Neil,P. McConnell,Paul Henderson,Seton J Henderson,M. Sim,S. Kennedy-Hay,C. McParland,L. Rooney,N. Baxter,D. Pogson,S. Rose,Z. Daly,L. Brimfield,Mandeep Phull,M. Hussain,T. Pogreban,L. Rosaroso,E. Salciute,L. Grauslyte,David Brealey,Eamon P. Raith,N. MacCallum,G. Bercades,I. Hass,D. Smyth,A. Reyes,G. Martir,I. D. Clement,K. Webster,C. Hays,A. Gulati,Luke Hodgson,M. Margarson,Refujia Gomez,Y. Baird,Y. Thirlwall,L. Folkes,A. Butler,E. Meadows,Shona C Moore,D. Raynard,Helen C. Fox,L. Riddles,K. King,S. Kimber,G. Hobden,Anne Marie McCarthy,V. Cannons,I. Balagosa,I. Chadbourn,A. Gardner,D. Horner,D. McLaughlanv,B. Charles,N. Proudfoot,T. Marsden,L. McMorrow,B. Blackledge,J. Pendlebury,Alison G. Harvey,E. Apetri,C. Basikolo,L. Catlow,R. Doonan,K. Knowles,S. Lee,David A. Lomas,C. Lyons,Joseph Perez,M. Poulaka,M. Slaughter,K. Slevin,V. Thomas,David W. Walker,Jennifer R. Harris,A. Drummond,R. Tully,J. Dearden,J. Philbin,S. Munt,C. Rishton,G. O'Connor,M. Mulcahy,E. Dobson,J. Cuttler,M. Edward,Jill M. Norris,K. Hanson,Alexis Poole,Alistair Rose,B. Sloan,S. Buckley,H. Brooke,E. Smithson,R. Charlesworth,R. Sandhu,M. Thirumaran,V. Wagstaff,J. C. Suarez,Agilan Kaliappan,M. Vertue,Andrew G. Nicholson,J. Riches,A. Solesbury,L. Kittridge,M. Forsey,G. Maloney,John B. Cole,R. Davies,H. Hill,E L Thomas,A. Williams,D. Duffin,B. Player,Jayachandran Radhakrishnan,Spencer B. Gibson,A. Lyle,F. McNeela,Brijesh V. Patel,M. Gummadi,G. Sloane,N. Dormand,S. Salmi,Z. Farzad,D. Cristiano,K. Liyanage,V. Thwaites,M. Varghese,M. Meredith,Gordon B. Mills,J. Willson,K. Harrington,B. Lenagh,K. Cawthron,S. Masuko,A. Raithatha,K. Bauchmuller,M. Wiles,N. Ahmad,Jack Barker,Y. Jackson,F. Kibutu,Sara W. Bird,G. Watson,Javier Martin,E. Bevan,C. W. Brown,D. Trodd,K. English,Graeme I. Bell,L. Wilcox,A. Katary,S. Gopal,V. Lake,N. Harris,S. Metherell,Elizabeth J. Radford,F. Moore,H. Bancroft,J. Daglish,M. Sangombe,M. Carmody,Johanna Rhodes,M. Bellamy,Atul Garg,A. Kuravi,E. Virgilio,P. Ranga,Javed Butler,L. Botfield,C. Dexter,Jason Fletcher,P. Shanmugasundaram,G. Hambrook,I. Burn,K. Manso,D. Thornton,J. Tebbutt,R. Penn,J. Hulme,Sabah N. A. Hussain,Z. Maqsood,Sarah B. Joseph,J. Colley,A. Hayes,C. Ahmed,R. Haq,S. Clamp,Rakesh Kumar,M. Purewal,B. Baines,M. Frise,N. Jacques,H. Coles,J. Caterson,S. G. Rai,M. Brunton,E. Tilney,L. Keating,Andrew Walden,David Antcliffe,Stephen J. Brett,Anthony C. Gordon,M. Templeton,Rocio Rojo,D. Banach,S. S. Arias,Z. Fernandez,P. Coghlan,D. Williams,Catherine Jardine,J. Bewley,Katie Sweet,L. Grimmer,Randall S. Johnson,Z. Garland,B. Gumbrill,C. Phillips,L. Ortiz-Ruiz de Gordoa,E. Peasgood,Ascanio Tridente,K. Shuker,S. Greer,C. Lynch,C. Pothecary,L. Roche,B. Deacon,K. Turner,Jai Rup Singh,G. S. Howe,P. Paul,Michael Gill,I. Wynter,V. Ratnam,S. Shelton,Jay Naisbitt,J. Melville,R. Baruah,Siouxzy Morrison,A. McGregor,V. Parris,M. Mpelembue,S. Srikaran,C. Dennis,A. Sukha,M. Verlander,K. Holding,K. Riches,C. Downes,C. Swan,A. Rostron,Ajit Roy,L. Woods,S. Cornell,F. Wakinshaw,Ben Creagh-Brown,H. Blackman,A. Salberg,E. N. Smith,S. Donlon,S. Mtuwa,N. Michalak-Glinska,S. Stone,C. Beazley,V. Pristopan,N. Nikitas,L. Lankester,Christine A. Wells,A. S. Raj,Katherine Fletcher,R. Khade,G. Tsinaslanidis,Michael MacMahon,Stephen J. Fowler,T. Coventry,Richard B. Stewart,L. Wren,E. Mwaura,L. Mew,D. Scaletta,Frances M K Williams,K. Inweregbu,N. Lancaster,Matthew Cunningham,A. Daniels,L. Harrison,S. Hope,S Jones,A. Crew,G. Wray,John N. S. Matthews,R. Crawley,J. Carter,I. Birkinshaw,J. Ingham,Z. Scott,H. Pearson,K. Howard,R. Joy,S. Roche,M. Clark,S. Purvis,Alanna C. Morrison,David P. Strachan,S. Clements,K. Black,Chetan Parmar,A. Altabaibeh,Kenneth J. Simpson,L. Mostoles,K. Gilbert,L. Ma,A. Alvaro,Mark G. Thomas,B. Faulkner,R. Worner,Kate Hayes,E. Gendall,H. Blakemore,B. Borislavova,E. Goff,Alan Vuylsteke,L. Mwaura,J. Zamikula,L Garner,A. Mitchell,S. Mepham,L. Cagova,A. Fofano,H. Holcombe,K. Praman,Tamas Szakmany,A. E. Heron,S. Cherian,S. Cutler,A. Roynon-Reed,G. Randell,K. Convery,K. Stammers,D. Fottrell-Gould,L. Hudig,J. Keshet-Price,Mark J. Peters,L. O'Neill,Swapan K. Ray,H. Belfield,T. McHugh,Graeme Jones,O. Akinkugbe,A. Tomas,E. Abaleke,E. Beech,H. Meghari,S. Yussuf,A. Bamford,B. Hairsine,E. Dooks,F. Farquhar,S. Packham,H. Bates,Lawrence Armstrong,C. Kaye,A. Allan,J. Medhora,J. Liew,A. Botello,F. Anderson,Rebecca Cusack,H. Golding,K. Prager,Thomas N. Williams,S. Leggett,K. Golder,M. Male,O. Jones,K. Criste,M. Marani,V. Anumakonda,V. Amin,K. Karthik,R. Kausar,E. Anastasescu,K. Reid,Mari Smith,Anil Hormis,Rosie M. Walker,T. Duncan,A. Uriel,Andrew Ustianowski,H. T-Michael,M. Bruce,K. Connolly,Kenneth Smith,Roland Partridge,Darren K. Griffin,M. Mupudzi,N. Muchenje,Dori-Ann Martin,H. Filipe,C. Eastgate,C. Jackson,Andrew Gratrix,L. Foster,Victoria Martinson,E. Stones,C. Abernathy,P. Parkinson,A. Reed,C. Prendergast,Peter Rogers,M. Woodruff,R. Shokkar,S Kaul,A. Barron,C. Collins,S. Beavis,A. Whileman,K. Dale,J. Hawes,K. Pritchard,R. Gascoyne,L. Stevenson,R. Jha,L. Lim,V. Krishnamurthy,Roy Parker,I. Turner-Bone,L. Wilding,A. Reddy,S. Whiteley,E. Wilby,C. Howcroft,A. Aspinwall,Sue Charlton,B. Ogg,Donna J. Menzies,Richard Pugh,E. Allan,R. Lean,F. Davies,J. Easton,X. Qiu,Shriya B. Kumar,K. Darlington,G. Houston,P. O'Brien,T. Geary,Jay Allan,A. Meikle,Grant L. Hughes,M. Balasubramaniam,S. Latham,E. McKenna,R. Flanagan,S. Sathe,Emma L. Davies,M. Chablani,A. Kirkby,K. Netherton,S. Archer,Bryan Yates,C. Ashbrook-Raby,Sarah Cole,M. Casey,L. Cabrelli,Stephen Chapman,A. Hutcheon,C. Whyte,C. Almaden-Boyle,Natalie Pattison,Claudina Cruz,A. Vochin,H. Kent,Adri A. M. Thomas,S. Murdoch,B. David,M. Penacerrada,G. Lubimbi,V. Bastion,R. Wulandari,Roberto Lorusso,J. Valentine,D. Clarke,A. Serrano-Ruiz,S. Hierons,C. Eckbad,L. Ramos,C. Demetriou,S. Mitchard,K. White,Nicholas J. White,Steven J. Pitts,D. Branney,J. Frankham,M. Watters,H. Langton,Rachel Prout,V. Page,T. Varghes,A. Cowton,A. Kay,K. Potts,M. Birt,Matthew Peter Kent,A. Wilkinson,E. B. Jude,V. Turner,H. Savill,J. McCormick,M. Coulding,S. Siddiqui,O. Mercer,H. Rehman,D. Potla,N. Capps,David S. Donaldson,H. Button,Terry Martin,K. Hard,A. Agasou,L. Tonks,T. Arden,Patricia A. Boyle,M. Carnahan,J. Strickley,Christopher M. Adams,D. Childs,R. Rikunenko,M. Leigh,M. Breekes,R. Wilcox,A. Bowes,H. Tiveran,F. Hurford,J. Summers,Austin Carter,Y. Hussain,L. Ting,A. Javaid,N. Motherwell,H. Moore,H. Millward,S. Jose,N. Schunki,A. Noakes,C. Clulow,G. Sadera,Reni Jacob,Chris Jones,M. Blunt,Z. Coton,H. Curgenven,S. M. Ally,K. Beaumont,M. Elsaadany,K. Fernandes,I. Ali Mohamed Ali,H. Rangarajan,V. Sarathy,S. Selvanayagam,D. Vedage,M. White,N. Truman,Srikanth Chukkambotla,S. Keith,J. Cockerill-Taylor,J. Ryan-Smith,R. Bolton,P. Springle,J. Dykes,Jo Thomas,Muzamil Majid Khan,M. T. Hijazi,E. Massey,G. Croston,Henrik Reschreiter,Julie Camsooksai,S. Patch,S. Jenkins,C. Humphrey,B. Wadams,M. Msiska,O. Adanini,B. Attwood,P. Parsons,Kate Tatham,S. Jhanji,E. Black,A. Dela Rosa,R. Howle,B. Thomas,T. Bemand,R. Raobaikady,R. Saha,Nikki Staines,A. Daniel,J. Finn,J. Hutter,P. Doble,C. Shovelton,C. Pawley,T. Kannan,Michael Hill,E. Combes,S. Monnery,T. Joefield,M. Popescu,M. Thankachen,M. Oblak,Jeff Little,S. McIvor,A. Brady,H. Whittle,H. Prady,R. Chan,A. Ahmed,Andrew D. Morris,C. Gibson,E. Gordon,S. Keenan,H. Quinn,S. Benyon,S. Marriott,L. Zitter,L. Park,K. Baines,M. Lyons,M. Holland,N. Keenan,M. Young,S. Garrioch,J. Dawson,M. Tolson,B. Scholefield,R. Bi,Neil Richardson,N. Schumacher,T. Cosier,G. Millen,A. Higham,S. Turki,L. Allen,N. Crisp,T. Hazleton,A. Knight,J. Deery,C. Price,S. Turney,S. Tilbey,E. Beranova,Derek W. Wright,L. George,S. Twiss,S. Wadd,K. Postlethwaite,P. Gondo,B. Masunda,A. Kayani,B. Hadebe,J. Whiteside,N. Clarke,Phil Donnison,F. Trim,I. Leadbitter,D. Butcher,S. O'Sullivan,B. Purewal,Scott C. Bell,V. Rivers,R. O'Leary,J. Birch,E. Collins,Stephen K. Anderson,K. Hammerton,E. Andrews,K. Burns,I. Edmond,A. Todd,J. Donnachie,P. Turner,L. Prentice,L. Symon,N. Runciman,F. Auld,M. Halkes,P. Mercer,L. Thornton,G. Debreceni,J. Wilkins,V. Crickmore,G. Subramanian,Robert Marshall,C. Jennings,M. Latif,L. Bunni,M. Spivey,S. Bean,K. Burt,Vanessa Linnett,J. Ritzema,A. Sanderson,W. McCormick,M. Bokhari,R. Kapoor,D. Loader,A. Ayers,W. Harrison,J. North,Z. Belagodu,R. Paramsothy,O. Olufuwa,A. Gherman,B. Fuller,C. Stuart,O. Kelsall,Carrie A. Davis,L. Wild,Henry Wood,Jessica Thrush,A. Durie,K. Austin,K. Archer,P. Anderson,C. Vigurs,C. Thorpe,E. Knights,N. Boyle,Alkes L. Price,A. Kubisz-Pudelko,D. Wood,Amy Lewis,S. Board,L. Pippard,John R. B. Perry,K. Beesley,A. Rattray,E. Lee,L. Lennon,K. Douglas,D. Bell,R. Boyle,L. Glass,M. Nauman Akhtar,K. Dent,D. Potoczna,S. Pearson,E. Horsley,S. Spencer,D. Mullan,D. Skinner,J. Gaylard,R. Barber,C. Hewitt,A. Hilldrith,S. Shepardson,M. Wills,K. Jackson-Lawrence,A. Gupta,E. Timlick,C. Gorman,Igor Otahal,A. Gales,S. Coetzee,Christian Sell,M. Raj,M. Peiu,S. Quaid,E. Watson,Katherine S. Elliott,J. Mallinson,B. Chandler,A. Turnbull,C. Finch,C. Holl,J.A. Cooper,Anthony Evans,W. Khaliq,Andrea M. Collins,E. T. Gude,N. Love,L. van Koutrik,John A. Hunt,D. Kaye,Eva Fisher,A. Brayne,V. Tuckey,P. Jackson,J. Parkin,A. Tariq,Henry Houlden,A. Tucci,John Hardy,E. Moncur,J. Highgate,A. Cowley,A. Mitra,R. Stead,T. Behan,C. Burnett,M. Newton,E. Heeney,R. Pollard,J. Hatton,Amita Patel,Vidya Kasipandian,S. Allibone,R. M. Genetu,L. O'Brien,Z. Omar,E. Perkins,Kevin A. Davies,D. Tetla,B. Shelley,V. Irvine,Samantha J. Williams,Patricia Williams,J. Goodsell,R. Tutton,L. Bough,B. Winter-Goodwin,R. Kitson,J. Pinnell,Anthony J. Wilson,T. Nortcliffe,T. Wood,M. Home,K. Holdroyd,Matthew R. Robinson,R. Shaw,J. Greig,M. Brady,A. Haigh,L. Matupe,M. Usher,S. Mellor,S. Dale,L. Gledhill,L. Shaw,G. Turner,Donna Kelly,B. Anwar,Heather L. Riley,H. Sturgeon,A. Ali,L. Thomis,D. Melia,A. Dance,SE Humphreys,I. Frost,V. Gopal,Jo Godden,A. Holden,S. Swann,Tony Smith,M. Clapham,U. Poultney,R. Harper,P. Rice,R. Reece-Anthony,B. Gurung,S. Moultrie,M. Odam,Andreas Mayer,A. Bellini,A. Pickard,J. Bryant,N. Roe,J. Sowter,K. Lang,Jenny C. Taylor,P. Barry,Maria Hobrok,H. Tench,R. Wolf-Roberts,H. McGuinness,R. Loosley,Daniel B Hawcutt,L. Rad,L. O'Malley,P. Saunderson,G. Seddon,Tim J. Anderson,N. Rogers,J. Ruddy,M. Harkins,C. Beith,A. McAlpine,L. Ferguson,Paul Grant,S. MacFadyen,M. McLaughlin,T. Baird,S. Rundell,B. Welsh,R. Hamill,F. Fisher,J. Gregory,Campbell A,S. Smuts,J Kenneth Baillie,J Kenneth Baillie,Gail Carson,Beatrice Alex,B. Bach,Wendy S. Barclay,Debby Bogaert,Meera Chand,Graham S Cooke,Annemarie B Docherty,Jake Dunning,A. da Silva Filipe,Tom Fletcher,Christopher A Green,Ewen M Harrison,Julian A. Hiscox,Ho A. Y. W.,Peter Horby,Samreen Ijaz,S. Khoo,W. S. Lim,Alexander J. Mentzer,Laura Merson,Alison M. Meynert,Mahdad Noursadeghi,Massimo Palmarini,William A. Paxton,Georgios Pollakis,Nicholas Price,Andrew Rambaut,David Robertson,Vanessa Sancho-Shimizu,Janet T Scott,T I de Silva,Louise Sigfrid,Tom Solomon,Shiranee Sriskandan,David I. Stuart,R.S. Tedder,E. Thomson,Alfred A.R. Thompson,Ryan S Thwaites,L Turtle,Maria Zambon,Hayley Hardwick,Chloe Donohue,Ronan A Lyons,Lisa Norman,Riinu Pius,Thomas M Drake,Cameron J Fairfield,Stephen R Knight,Kenneth A. McLean,Derek Murphy,C. A. Shaw,Jo Dalton,Michelle Girvan,Egle Saviciute,Stuart K. Roberts,Janet Harrison,Laura Marsh,Marie Connor,Sophie Halpin,Carrol Gamble,Gary Leeming,Murray Wham,William Greenhalf,V. Shaw,Sarah D. McDonald,Andrea Ganna,Patrick Sulem,D A van Heel,M. Cordioli,Gardar Sveinbjornsson,M. E. K. Niemi,Janie F. Shelton,A. J. Shastri,C. Ye,C. H. Weldon,T. Filshtein-Sonmez,D. Coker,A. Symons,J. Esparza-Gordillo,Stella Aslibekyan,Adam Auton,J. E. Krieger,E. Marques,C. E. Jannes,Francesca Mari,S. Daga,Margherita Baldassarri,Elisa Benetti,Simone Furini,Chiara Fallerini,Francesca Fava,Floriana Valentino,G. Doddato,Annarita Giliberti,Rossella Tita,Sara Amitrano,Mirella Bruttini,S. Croci,I. Meloni,A. M. Pinto,E. Frullanti,Maria Antonietta Mencarelli,C. L. Rizzo,Francesca Montagnani,L. Di Sarno,A. Tommasi,Marta Palmieri,Arianna Emiliozzi,M. Fabbiani,Barbara Rossetti,Giacomo Zanelli,Elena Bargagli,Laura Bergantini,Miriana d'Alessandro,Paolo Cameli,D. Bennet,Federico Anedda,Simona Marcantonio,Sabino Scolletta,Federico Franchi,Maria Antonietta Mazzei,S. Guerrini,Edoardo Conticini,Luca Cantarini,Bruno Frediani,D. Tacconi,C. Spertilli,M. Feri,Abele Donati,R. Scala,L. Guidelli,G. Spargi,M. Corridi,C. Nencioni,L. Croci,G. P. Caldarelli,M. Spagnesi,P. Piacentini,M. Bandini,E. Desanctis,S. Cappelli,A. Canaccini,A. Verzuri,V. Anemoli,A. Ognibene,M. Vaghi,A d'Arminio Monforte,Esther Merlini,M. U. Mondelli,S. Mantovani,S. Ludovisi,Massimo Girardis,S. Venturelli,M. Sita,Andrea Cossarizza,A. Antinori,Alessandra Vergori,Stefano Rusconi,M. Siano,A. Gabrieli,Agostino Riva,Daniela Francisci,Elisabetta Schiaroli,P. G. Scotton,F. Andretta,S. Panese,R. Scaggiante,F. Gatti,S. G. Parisi,Francesco Castelli,M. E. Quiros-Roldan,P. Magro,Isabella Zanella,M. Della Monica,Carmelo Piscopo,Mario Capasso,Roberta Russo,Immacolata Andolfo,Achille Iolascon,G. Fiorentino,M. Carella,Marco Castori,Giuseppe Merla,Filippo Aucella,P. Raggi,C. Marciano,R. Perna,Matteo Bassetti,A. Di Biagio,M. Sanguinetti,L. Masucci,Serafina Valente,Marco Mandalà,A. Giorli,L. Salerni,P. Zucchi,P. Parravicini,E. Menatti,S. Baratti,T. Trotta,F. Giannattasio,G. Coiro,F. Lena,D. A. Coviello,Cristina Mussini,G. Bosio,E. Martinelli,Sandro Mancarella,L. Tavecchia,L. Crotti,N. Picchiotti,M. Gori,C. Gabbi,M. Sanarico,S. Ceri,P. Pinoli,F. Raimondi,F. Biscarini,A. Stella,Xia Shen,Xia Shen,Chris P. Ponting,Angie Fawkes,Albert Tenesa,Albert Tenesa,Mark J. Caulfield,Richard H Scott,K Rowan,Lee Murphy,Peter J. M. Openshaw,Peter J. M. Openshaw,Malcolm G Semple,Veronique Vitart,James F. Wilson +1449 more
TL;DR: The GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2244 critically ill Covid-19 patients from 208 UK intensive care units is reported, finding evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease.
Journal ArticleDOI
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.
Jian Yang,Andrew Bakshi,Zhihong Zhu,Gibran Hemani,Gibran Hemani,Anna A. E. Vinkhuyzen,Sang Hong Lee,Sang Hong Lee,Matthew R. Robinson,John R. B. Perry,Ilja M. Nolte,Jana V. van Vliet-Ostaptchouk,Harold Snieder,Tõnu Esko,Lili Milani,Reedik Mägi,Andres Metspalu,Anders Hamsten,Patrik K. E. Magnusson,Nancy L. Pedersen,Erik Ingelsson,Erik Ingelsson,Nicole Soranzo,Nicole Soranzo,Matthew C. Keller,Naomi R. Wray,Michael E. Goddard,Peter M. Visscher +27 more
TL;DR: It is demonstrated using simulations based on whole-genome sequencing data that ∼97% and ∼68% of variation at common and rare variants, respectively, can be captured by imputation, and evidence that height- and BMI-associated variants have been under natural selection is found.
Journal ArticleDOI
Causal associations between risk factors and common diseases inferred from GWAS summary data
Zhihong Zhu,Zhili Zheng,Zhili Zheng,Futao Zhang,Yang Wu,Maciej Trzaskowski,Robert Maier,Matthew R. Robinson,John J. McGrath,Peter M. Visscher,Naomi R. Wray,Jian Yang +11 more
TL;DR: A generalized summary-based Mendelian Randomization (GSMR) method which uses summary-level data from GWAS to test for causal associations of health risk factors with common diseases.