Fleur C. Garton

TL;DR: Despite sprint performance relying on many gene variants and environment, the % sprint time variance explained by ACE and ACTN3 is substantial at the elite level and might be the difference between a world record and only making the final.

TL;DR: Of the polymorphisms associated with elite power and sprint performance, the α-actinin-3 R577X polymorphism provides the most consistent results and is the only gene that shows a genotype and performance association across multiple cohorts of elite power athletes.

TL;DR: This study did not identify a panel of genomic variants common to these elite endurance athlete groups, and since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies.

TL;DR: It is shown that α-Actinin-3 deficiency results in increased calcineurin activity in mouse and human skeletal muscle and enhanced adaptive response to endurance training, and that the sarcomeric α-actinins play a role in the regulation of calcineURin signaling.

TL;DR: Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk and provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality.