A
Allan F. McRae
Researcher at University of Queensland
Publications - 197
Citations - 15258
Allan F. McRae is an academic researcher from University of Queensland. The author has contributed to research in topics: DNA methylation & Genome-wide association study. The author has an hindex of 54, co-authored 181 publications receiving 11382 citations. Previous affiliations of Allan F. McRae include AgResearch & University of Edinburgh.
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Journal ArticleDOI
DNA methylation age of blood predicts all-cause mortality in later life.
Riccardo E. Marioni,Riccardo E. Marioni,Sonia Shah,Allan F. McRae,Brian H. Chen,Elena Colicino,Sarah E. Harris,Jude Gibson,Anjali K. Henders,Paul Redmond,Simon R. Cox,Alison Pattie,Janie Corley,Lee Murphy,Nicholas G. Martin,Grant W. Montgomery,Andrew P. Feinberg,M. Daniele Fallin,M. Daniele Fallin,Michael L. Multhaup,Andrew E. Jaffe,Roby Joehanes,Roby Joehanes,Joel Schwartz,Allan C. Just,Kathryn L. Lunetta,Kathryn L. Lunetta,Joanne M. Murabito,Joanne M. Murabito,John M. Starr,Steve Horvath,Andrea A. Baccarelli,Daniel Levy,Peter M. Visscher,Peter M. Visscher,Naomi R. Wray,Ian J. Deary +36 more
TL;DR: DNA methylation-derived measures of accelerated aging are heritable traits that predict mortality independently of health status, lifestyle factors, and known genetic factors.
Journal ArticleDOI
DNA methylation-based measures of biological age: meta-analysis predicting time to death
Brian H. Chen,Riccardo E. Marioni,Riccardo E. Marioni,Elena Colicino,Marjolein J. Peters,Cavin K. Ward-Caviness,Pei-Chien Tsai,Nicholas S. Roetker,Allan C. Just,Ellen W. Demerath,Weihua Guan,Jan Bressler,Myriam Fornage,Myriam Fornage,Stephanie A. Studenski,Amy R. Vandiver,Ann Zenobia Moore,Toshiko Tanaka,Douglas P. Kiel,Liming Liang,Pantel S. Vokonas,Joel Schwartz,Kathryn L. Lunetta,Kathryn L. Lunetta,Joanne M. Murabito,Joanne M. Murabito,Stefania Bandinelli,Dena G. Hernandez,David Melzer,Mike A. Nalls,Luke C. Pilling,Timothy Ryan Price,Andrew B. Singleton,Christian Gieger,Rolf Holle,Anja Kretschmer,Florian Kronenberg,Sonja Kunze,Jakob Linseisen,Christine Meisinger,Wolfgang Rathmann,Melanie Waldenberger,Peter M. Visscher,Peter M. Visscher,Sonia Shah,Naomi R. Wray,Allan F. McRae,Oscar H. Franco,Albert Hofman,Albert Hofman,André G. Uitterlinden,Devin Absher,Themistocles L. Assimes,Morgan E. Levine,Ake T. Lu,Philip S. Tsao,Philip S. Tsao,Lifang Hou,JoAnn E. Manson,Cara L. Carty,Andrea Z. LaCroix,Alexander P. Reiner,Alexander P. Reiner,Tim D. Spector,Andrew P. Feinberg,Daniel Levy,Andrea A. Baccarelli,Andrea A. Baccarelli,Joyce B. J. van Meurs,Jordana T. Bell,Annette Peters,Ian J. Deary,James S. Pankow,Luigi Ferrucci,Steve Horvath +74 more
TL;DR: Evidence that epigenetic age predicts all-cause mortality above and beyond chronological age and traditional risk factors is strengthened and estimates that incorporate information on blood cell counts lead to highly significant associations with all- Cause mortality are demonstrated.
Journal ArticleDOI
A versatile gene-based test for genome-wide association studies
Jimmy Z. Liu,Allan F. McRae,Dale R. Nyholt,Sarah E. Medland,Naomi R. Wray,Kevin M. Brown,Nicholas K. Hayward,Grant W. Montgomery,Peter M. Visscher,Nicholas G. Martin,Stuart MacGregor +10 more
TL;DR: This work derived a versatile gene-based test for genome-wide association studies (GWAS) that has the potential to identify novel associated genes; provide a basis for selecting SNPs for replication; and be directly used in network (pathway) approaches that require per-gene association test statistics.
Journal ArticleDOI
DNA methylation profiles in monozygotic and dizygotic twins
Zachary Kaminsky,Thomas Tang,Sun Chong Wang,Sun Chong Wang,Carolyn Ptak,Gabriel Oh,Albert H.C. Wong,Laura A. Feldcamp,Carl Virtanen,Jonas Halfvarson,Curt Tysk,Allan F. McRae,Peter M. Visscher,Grant W. Montgomery,Irving I. Gottesman,Nicholas G. Martin,A. Petronis +16 more
TL;DR: The first annotation of epigenetic metastability of ∼6,000 unique genomic regions in MZ twins is provided, suggesting that molecular mechanisms of heritability may not be limited to DNA sequence differences.
Journal ArticleDOI
Epigenetic Signatures of Cigarette Smoking
Roby Joehanes,Allan C. Just,Riccardo E. Marioni,Luke C. Pilling,Lindsay M. Reynolds,Pooja R. Mandaviya,Weihua Guan,Tao Xu,Cathy E. Elks,Stella Aslibekyan,Hortensia Moreno-Macías,Jennifer A. Smith,Jennifer A. Brody,Radhika Dhingra,Paul Yousefi,James S. Pankow,Sonja Kunze,Sonia Shah,Allan F. McRae,Kurt Lohman,Jin Sha,Jin Sha,Devin Absher,Luigi Ferrucci,Wei Zhao,Ellen W. Demerath,Jan Bressler,Megan L. Grove,Tianxiao Huan,Tianxiao Huan,Chunyu Liu,Chunyu Liu,Chunyu Liu,Michael M. Mendelson,Chen Yao,Douglas P. Kiel,Annette Peters,Rui Wang-Sattler,Peter M. Visscher,Naomi R. Wray,John M. Starr,Jingzhong Ding,Carlos J. Rodriguez,Nicholas J. Wareham,Marguerite R. Irvin,Degui Zhi,Myrto Barrdahl,Paolo Vineis,Srikant Ambatipudi,André G. Uitterlinden,Albert Hofman,Joel Schwartz,Elena Colicino,Lifang Hou,Pantel S. Vokonas,D. Hernandez,Andrew B. Singleton,Stefania Bandinelli,Stephen Turner,Erin B. Ware,Alicia K. Smith,Torsten Klengel,Elisabeth B. Binder,Bruce M. Psaty,Kent D. Taylor,Sina A. Gharib,Brenton R. Swenson,Liming Liang,Dawn L. DeMeo,George T. O'Connor,Zdenko Herceg,Kerry J. Ressler,Karen N. Conneely,N. Sotoodehnia,Sharon L.R. Kardia,David Melzer,Andrea A. Baccarelli,Joyce B. J. van Meurs,Isabelle Romieu,Donna K. Arnett,Ken K. Ong,Yongmei Liu,M. Waldenberger,Ian J. Deary,Myriam Fornage,Daniel Levy,Stephanie J. London +86 more
TL;DR: Cigarette smoking has a broad impact on genome-wide methylation that, at many loci, persists many years aftersmoking cessation, indicating a pattern of persistent altered methylation, with attenuation, after smoking cessation.