S
Susan Krezoski
Researcher at University of Wisconsin–Milwaukee
Publications - 25
Citations - 506
Susan Krezoski is an academic researcher from University of Wisconsin–Milwaukee. The author has contributed to research in topics: Metallothionein & Cotransporter. The author has an hindex of 13, co-authored 25 publications receiving 477 citations. Previous affiliations of Susan Krezoski include Medical College of Wisconsin.
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Journal ArticleDOI
Mammalian metallothionein in toxicology, cancer, and cancer chemotherapy
Mohammad Ali Namdarghanbari,William J. Wobig,Susan Krezoski,Niloofar M. Tabatabai,David H. Petering +4 more
TL;DR: The present paper centers on mammalian metallothionein 1 and 2 in relationship to cell and tissue injury beginning with its reaction with Cd2+ and then considering its role in the toxicology and chemotherapy of both metals and non-metal electrophiles and oxidants.
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Zinc binding ligands and cellular zinc trafficking: Apo-metallothionein, glutathione, TPEN, proteomic zinc, and Zn-Sp1
Ujala Rana,Rajendra K. Kothinti,Jeffrey Meeusen,Niloofar M. Tabatabai,Susan Krezoski,David H. Petering +5 more
TL;DR: The results help to rationalize the steady state presence of cellular apo-MT in the midst of the many, diverse members of the Zn-proteome and show that TPEN is a robust intracellular chelator of proteomic Zn(2+).
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Apo-metallothionein emerging as a major player in the cellular activities of metallothionein.
David H. Petering,Jianyu Zhu,Susan Krezoski,Jeffrey Meeusen,Christy Kiekenbush,Sara Krull,Todd Specher,Munira Dughish +7 more
TL;DR: Comparison in vitro and cellular experiments examined the relative reactivity of Zn- and apo-MT with nitric oxide species, showing that api-MT is much more reactive chemically and that in cells it may be a principal reactive species within the MT pool.
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Binding of cis-dichlorodiammine platinum(II) to metallothionein in Ehrlich cells
TL;DR: Isolated rat liver metallothionein is a major cellular site of binding of the platinum complex at concentrations which inhibit tumor growth.
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Surface Chemistry and Biological Pathogenicity of Silicates: An X-Ray Photoelectron Spectroscopic Study
TL;DR: In vitro experiments involving contact of the silicate with cultured murine Ehrlich cells have identified modifications in the surface chemistry of Al, Mg and Fe in the silicates and changes in cellular iron content.