Susan W. Craig

TL;DR: Pyer's patches are a highly enriched source of cells which have the potential to proliferate and differentiate into IgA-producing immunocytes and are far more efficient in seeding the gut of irradiated recipient rabbits with donor cells that give rise to immunoglobulin-producing cells than cells from peripheral blood or popliteal lymph nodes.

TL;DR: It is demonstrated that cardiac myOSin itself induces severe myocarditis and high titers of myosin autoantibodies in A/J, A.SW/SnJ, and A.CA/ SnJ mice, and it is found that susceptibility toMyocarditis induced by cardiacMyosin is influenced by the major histocompatibility complex and by genes not closely linked to the majorhistocompatible complex.

TL;DR: The sarcolemmal lattice, detected because vinculin is one of its molecular components, integrates the contractile apparatus with the sarcolemma during lengthening and shortening of the muscle cells.

TL;DR: The immunofluorescence data of this study are interpreted to mean that, in cardiac muscle, vinculin is a component of an extensive system of lateral attachment of myofibrils to the plasma membrane and its invaginations.

TL;DR: It is demonstrated that vinculin is not required for transmission of adhesive and traction forces but is necessary for myosin contractility-dependent adhesion strength and traction force and for the coupling of cell area and tractionforce.