S
Susana Mendez
Researcher at National Institutes of Health
Publications - 54
Citations - 6577
Susana Mendez is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Antigen & Hookworm vaccine. The author has an hindex of 34, co-authored 54 publications receiving 6369 citations. Previous affiliations of Susana Mendez include Complutense University of Madrid & Washington University in St. Louis.
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Journal ArticleDOI
CD4 + CD25 + regulatory T cells control Leishmania major persistence and immunity
Yasmine Belkaid,Yasmine Belkaid,Ciriaco A. Piccirillo,Susana Mendez,Ethan M. Shevach,David L. Sacks +5 more
TL;DR: It is shown that the persistence of Leishmania major in the skin after healing in resistant C57BL/6 mice is controlled by an endogenous population of CD4+CD25+ regulatory T cells, indicating that the equilibrium established between effector and regulatory T Cells in sites of chronic infection might reflect both parasite and host survival strategies.
Journal ArticleDOI
The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure
Yasmine Belkaid,Karl F. Hoffmann,Susana Mendez,Shaden Kamhawi,Mark C. Udey,Tom A. Wynn,David L. Sacks +6 more
TL;DR: A novel therapeutic approach to eliminate latency, infection reservoirs, and the risk of reactivation disease is suggested as sterile cure was achieved in IL-10–deficient and IL-4/IL-10 double-deficient mice.
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Toward a Defined Anti-Leishmania Vaccine Targeting Vector Antigens: Characterization of a Protective Salivary Protein
Jesus G. Valenzuela,Yasmine Belkaid,Mark Garfield,Susana Mendez,Shaden Kamhawi,Edgar Rowton,David L. Sacks,José M. C. Ribeiro +7 more
TL;DR: Results indicate that DTH response against saliva provides most or all of the protective effects of this vaccine and that salivary gland proteins or their cDNAs are viable vaccine targets against leishmaniasis.
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A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity.
TL;DR: The results extend to a natural infection model a role for Th1 cells in both acquired resistance and lesion formation, and document the remarkable avoidance of this response during a prolonged phase of parasite amplification in the skin.
Journal ArticleDOI
CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major.
Yasmine Belkaid,Esther von Stebut,Susana Mendez,Rosalia Lira,Elisabet Caler,Sylvie Bertholet,Mark C. Udey,David B. Sacks +7 more
TL;DR: The low dose, intradermal challenge model of cutaneous leishmaniasis reveals that CD8+ T cells play an essential role in both pathogenesis of and immunity to primary infection with L. major in the skin.