S
Susanne Kammler
Researcher at University of Düsseldorf
Publications - 8
Citations - 1197
Susanne Kammler is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: RNA splicing & splice. The author has an hindex of 8, co-authored 8 publications receiving 1125 citations. Previous affiliations of Susanne Kammler include Aarhus University.
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Journal ArticleDOI
RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters
Pascal Preker,Jesper Buus Nielsen,Susanne Kammler,Søren Lykke-Andersen,Marianne S. Christensen,Christophe K. Mapendano,Mikkel H. Schierup,Torben Heick Jensen +7 more
TL;DR: It is proposed that PROMPT transcription is a common characteristic of RNA polymerase II (RNAPII) transcribed genes with a possible regulatory potential and is positively correlated with gene activity.
Journal ArticleDOI
A Bidirectional SF2/ASF- and SRp40-Dependent Splicing Enhancer Regulates Human Immunodeficiency Virus Type 1 rev, env, vpu, and nef Gene Expression
TL;DR: A novel bidirectional exonic splicing enhancer that regulates the expression of the HIV-1 env, vpu, rev, and nef mRNAs is characterized and is highly conserved in most viral subtypes.
Journal ArticleDOI
A novel approach to describe a U1 snRNA binding site.
Marcel Freund,Corinna Asang,Susanne Kammler,Carolin Konermann,Jörg Krummheuer,Marianne Hipp,Imke Meyer,Wolfram Gierling,Stephan Theiss,Thorsten Preuss,Detlev Schindler,Jørgen Kjems,Heiner Schaal +12 more
TL;DR: In a data set of 5' splice site mutations of the human ATM gene, a significant correlation between the algorithmic classification and exon skipping is found, showing that the applicability of the proposed model reaches far beyond HIV-1 splicing.
Journal ArticleDOI
The sequence complementarity between HIV-1 5' splice site SD4 and U1 snRNA determines the steady-state level of an unstable env pre-mRNA.
Susanne Kammler,Cordula Leurs,Marcel Freund,Jörg Krummheuer,Kerstin Seidel,Thomas Ø. Tange,Mette K. Lund,Jørgen Kjems,Andreas Scheid,Heiner Schaal +9 more
TL;DR: The results demonstrate that the overall strength of hydrogen bonding between the 5' splice site, SD4, and the free 5' end of the U1 snRNA correlates with env expression efficiency, as long as env expression is suboptimal, and that a continuous stretch of 14 hydrogen bonds can lead to full env expression, as a result of stabilizing the pre-mRNA.
Journal ArticleDOI
The strength of the HIV-1 3' splice sites affects Rev function.
Susanne Kammler,Susanne Kammler,Marianne Otte,Ilona Hauber,Jørgen Kjems,Joachim Hauber,Heiner Schaal +6 more
TL;DR: It is proposed that Rev mediates a switch from exon to intron definition necessary for the expression of all intron-containing mRNAs and the rate limiting step of retroviral splicing, competing with Rev function seems to be exclusively determined by the functional strength of the 3' splice site.