Susanne Müller

TL;DR: Evidence that spinal cord injury directly causes increased risk for bacterial infection in mice as well as in patients is presented, demonstrating a secondary functional neurogenic immune deficiency (spinal cord injury-induced immune deficiency syndrome, SCI-IDS) sufficient to propagate clinically relevant infection in an injury level dependent manner.

TL;DR: It is demonstrated that the HPI model impeded a massive unspecific influx of donor‐derived myeloid cells into naive as well as tumor‐bearing brains and evidenced for the first time that microglia are able to up‐regulate CD45 and represent an inherent part of the CD45high population in the tumor context.

TL;DR: Improved neurological performance and survival may be due to neuroprotection by activation of GLT1 and a stimulation of neurotrophins resulting in an increased number of surviving neurons in the penumbra.

TL;DR: Systemic pretreatment with a sub-hypotensive, RAS-blocking dose of candesartan affords neuroprotection after focal ischemia, associated with increased activity of the neurotrophin BDNF/TrkB system.

TL;DR: The study provides evidence that the in vivo shear modulus of brain tissue correlates with neuronal density, and suggests that MRE may have diagnostic potential as a tool for image‐based quantification of neurodegenerative processes.