S
Sushil Kumar Singh
Researcher at Indian Institutes of Technology
Publications - 171
Citations - 2572
Sushil Kumar Singh is an academic researcher from Indian Institutes of Technology. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 25, co-authored 107 publications receiving 1916 citations. Previous affiliations of Sushil Kumar Singh include Indian Institute of Technology (BHU) Varanasi & Banaras Hindu University.
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Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring
TL;DR: Among the tested compounds, the most effective compounds with MIC value in the range of 6.25-25 microg/ml are 4a, 4n, 4z, 5a, 5b, 6a and 6b against three fungal strains viz.
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Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead.
Devendra Kumar,Ankit Ganeshpurkar,Dileep Kumar,Gyan Modi,Sanjeev K. Gupta,Sushil Kumar Singh +5 more
TL;DR: The review incorporates exhaustive literature reports on secretase inhibitors, γ-secretase modulators (GSMs) and α- secretase enhancers and the recent studies on the natural products as GSMs have also been included.
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Design, synthesis and mode of action of some benzothiazole derivatives bearing an amide moiety as antibacterial agents
TL;DR: Two active compounds (A07 and A10) with a membrane perturbing mode of action, and an intracellular mode ofaction due to binding with DNA along with potent activity against clinically relevant pathogens E. coli and S. aureus are provided.
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Naphthalene, a versatile platform in medicinal chemistry: Sky-high perspective
TL;DR: The naphthalene scaffold emerges as an important building block in drug discovery owing to its broad spectrum of biological activities through varying structural modifications.
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Estrogen signaling: An emanating therapeutic target for breast cancer treatment.
TL;DR: The important role of ER in development and progression of breast cancer is investigated, which is complicated by receptor's interaction with co-regulatory proteins, cross-talk with other signal transduction pathways and development of treatment strategies viz. selective estrogen receptor modulators (SERMs), selective estrogen receptors down regulators (SERDs), aromatase and sulphatase inhibitors.