Sushil Kumar Singh

TL;DR: Among the tested compounds, the most effective compounds with MIC value in the range of 6.25-25 microg/ml are 4a, 4n, 4z, 5a, 5b, 6a and 6b against three fungal strains viz.

TL;DR: The review incorporates exhaustive literature reports on secretase inhibitors, γ-secretase modulators (GSMs) and α- secretase enhancers and the recent studies on the natural products as GSMs have also been included.

TL;DR: Two active compounds (A07 and A10) with a membrane perturbing mode of action, and an intracellular mode ofaction due to binding with DNA along with potent activity against clinically relevant pathogens E. coli and S. aureus are provided.

TL;DR: The naphthalene scaffold emerges as an important building block in drug discovery owing to its broad spectrum of biological activities through varying structural modifications.

TL;DR: The important role of ER in development and progression of breast cancer is investigated, which is complicated by receptor's interaction with co-regulatory proteins, cross-talk with other signal transduction pathways and development of treatment strategies viz. selective estrogen receptor modulators (SERMs), selective estrogen receptors down regulators (SERDs), aromatase and sulphatase inhibitors.