S
Sudhir Kumar Singh
Researcher at Ben-Gurion University of the Negev
Publications - 28
Citations - 319
Sudhir Kumar Singh is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Hyaluronate lyase & Mode of action. The author has an hindex of 10, co-authored 28 publications receiving 243 citations. Previous affiliations of Sudhir Kumar Singh include North Eastern Hill University & Central Drug Research Institute.
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Design, synthesis and mode of action of some benzothiazole derivatives bearing an amide moiety as antibacterial agents
TL;DR: Two active compounds (A07 and A10) with a membrane perturbing mode of action, and an intracellular mode ofaction due to binding with DNA along with potent activity against clinically relevant pathogens E. coli and S. aureus are provided.
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Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles.
TL;DR: Current understanding of the remarkable ability of certain kinesin-5 motors to switch directionality when moving along MTs is summarized.
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Characterization of a Highly pH Stable Chi-Class Glutathione S-Transferase from Synechocystis PCC 6803.
TL;DR: The characterization of a highly pH stable GST from the model cyanobacterium- Synechocystis PCC 6803 and it is shown that cyanobacterial GST sll0067 is catalytically efficient compared to the best mammalian enzymes.
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The mRNA capping enzyme of Saccharomyces cerevisiae has dual specificity to interact with CTD of RNA Polymerase II
Akhilendra Pratap Bharati,Neha Singh,Vikash Kumar,Md. Kashif,Amit Kumar Singh,Priyanka Singh,Sudhir Kumar Singh,Mohammad Imran Siddiqi,Timir Tripathi,Md. Sohail Akhtar +9 more
TL;DR: It is reported that the Saccharomyces cerevesiae RNA guanylyltransferase (Ceg1) has dual specificity and interacts not only with Ser5P but also with Ser7P of the CTD, essential for the unconditional growth and efficient priming of the mRNA capping complex.
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Dual targeting of MDM2 with a novel small-molecule inhibitor overcomes TRAIL resistance in cancer
Anup Kumar Singh,Shikha S. Chauhan,Sudhir Kumar Singh,Ved Vrat Verma,Akhilesh Kumar Singh,Rakesh K. Arya,Shrankhla Maheshwari,Md. Sohail Akhtar,Jayanta Sarkar,Vivek M. Rangnekar,Prem M. S. Chauhan,Dipak Datta +11 more
TL;DR: CP-7c was identified as a novel small-molecule inhibitor of MDM2 with a unique two-prong mechanism of action that sensitized TRAIL-resistant cancer cells to apoptosis by modulating theMDM2-p53-DR4/DR5 pathway.