S
Susumu Ito
Researcher at Harvard University
Publications - 2
Citations - 82
Susumu Ito is an academic researcher from Harvard University. The author has contributed to research in topics: Endoplasmic reticulum & Unfolded protein response. The author has an hindex of 2, co-authored 2 publications receiving 78 citations.
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Journal ArticleDOI
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
Jianxin Xie,Hao Zhu,Kevin Larade,Annie Ladoux,Ayden Seguritan,Michelle Chu,Susumu Ito,Roderick T. Bronson,Edward H. Leiter,Chen-Yu Zhang,Evan D. Rosen,H. Franklin Bunn +11 more
TL;DR: Four-week-old Ncb5or-/- mice have enhanced sensitivity to the diabetogenic agent streptozotocin, and NCB5OR appears to play a critical role in protecting pancreatic beta cells against oxidant stress.
Journal ArticleDOI
The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced lipotoxicity.
TL;DR: It is suggested that ER stress plays a critical role in palmitate-induced lipotoxicity both in vitro and in vivo.