S
Suzanne Lemieux
Researcher at Université du Québec
Publications - 21
Citations - 1851
Suzanne Lemieux is an academic researcher from Université du Québec. The author has contributed to research in topics: Natural killer cell & Spleen. The author has an hindex of 12, co-authored 21 publications receiving 1779 citations. Previous affiliations of Suzanne Lemieux include Institut national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Licensing of natural killer cells by host major histocompatibility complex class I molecules
Sung Jin Kim,Jennifer Poursine-Laurent,Steven M. Truscott,Lonnie Lybarger,Yun Jeong Song,Liping Yang,Anthony R. French,John B. Sunwoo,Suzanne Lemieux,Ted H. Hansen,Wayne M. Yokoyama +10 more
TL;DR: It is demonstrated that NK cells acquire functional competence through ‘licensing’ by self-MHC molecules, which results in two types of self-tolerant NK cells—licensed or unlicensed—and may provide new insights for exploiting NK cells in immunotherapy.
Journal ArticleDOI
Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell–mediated innate resistance to cytomegalovirus infection
Marie-Pierre Desrosiers,Agnieszka Kielczewska,J C. Loredo-Osti,Sonia Girard Adam,Andrew P. Makrigiannis,Suzanne Lemieux,Trung H.M. Pham,Melissa B. Lodoen,Kenneth Morgan,Lewis L. Lanier,Silvia M. Vidal +10 more
TL;DR: It is found that natural killer cell–activating receptor Ly49P specifically recognized MCMV-infected cells, dependent on the presence of the H2 k haplotype, and binding was blocked using antibodies to H-2Dk but not antibodies toH-2Kk.
Journal Article
Tolerance and Alloreactivity of the Ly49D Subset of Murine NK Cells
TL;DR: Self tolerance of the Ly49D subset can be achieved through coexpression of a sufficient level of self-specific inhibitory receptors, as correlated with an increased mean fluorescence intensity of Ly49C expression, as well as an increased percentage of Ly 49D+A/G2- compartment.
Journal ArticleDOI
Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I- deficient mice
Margarita Salcedo,Malena Andersson,Suzanne Lemieux,Luc Van Kaer,Benedict J. Chambers,Hans-Gustaf Ljunggren +5 more
TL;DR: The present results are discussed in relation to the role of MHC class I molecules and Ly49 receptors in shaping the NK cell repertoire and raise new questions about maintenance of self tolerance in theNK cell system.
Journal ArticleDOI
Allorecognition by murine natural killer cells: lysis of T-lymphoblasts and rejection of bone-marrow grafts.
Thaddeus C. George,Yik Yeung Lawrence Yu,Jingxuan Liu,C. Davenport,Suzanne Lemieux,Earl Stoneman,Porunelloor A. Mathew,Vinay Kumar,Michael J. Bennett +8 more
TL;DR: Natural killer cells of inbred mice reject allogeneic bone marrow cells, and NK cells of F1 hybrid mice can reject parental bone‐marrow cells (hybrid resistance), which cannot be readily explained by the missing self hypothesis.