H
Hans-Gustaf Ljunggren
Researcher at Karolinska Institutet
Publications - 380
Citations - 36605
Hans-Gustaf Ljunggren is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: MHC class I & Immune system. The author has an hindex of 87, co-authored 345 publications receiving 32414 citations. Previous affiliations of Hans-Gustaf Ljunggren include Nova Southeastern University & National Institutes of Health.
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Journal ArticleDOI
In search of the 'missing self': MHC molecules and NK cell recognition.
Hans-Gustaf Ljunggren,Klas Kärre +1 more
TL;DR: In vivo studies with H-2-deficient targets that support the 'missing self' hypothesis are reviewed and testable predictions for how MHC class I molecules act in cases where they control a rate-limiting step in the NK cell-target interaction are derived.
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Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
TL;DR: It is shown that murine lymphoma cells selected for loss of H–2 expression are less malignant after low-dose inoculation in syngeneic hosts than are wild-type cells, and that the rejection of such cells is non-adaptive.
Journal ArticleDOI
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.
Takuya Sekine,André Perez-Potti,Olga Rivera-Ballesteros,Kristoffer Strålin,Jean Baptiste Gorin,Annika Olsson,Sian Llewellyn-Lacey,Habiba Kamal,Gordana Bogdanovic,Sandra Muschiol,David J. Wullimann,Tobias Kammann,Johanna Emgård,Tiphaine Parrot,Elin Folkesson,Olav Rooyackers,Lars Eriksson,Jan-Inge Henter,Anders Sönnerborg,Tobias Allander,Jan Albert,Morten Nielsen,Jonas Klingström,Sara Gredmark-Russ,Niklas K. Björkström,Johan K. Sandberg,David Price,Hans-Gustaf Ljunggren,Soo Aleman,Marcus Buggert +29 more
TL;DR: It is shown that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
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Association of class I major histocompatibility heavy and light chains induced by viral peptides.
TL;DR: A cell in which association of a major histocompatibility complex class I heavy chain with β2-microglobulin is induced by a peptide derived from influenza nucleoprotein is described.
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Empty MHC class I molecules come out in the cold
Hans-Gustaf Ljunggren,Nico J. Stam,Claes Öhlén,Jacques Neefjes,Petter Höglund,Marie-Thérèse Heemels,J Bastin,Ton N. Schumacher,Alain Townsend,Klas Kärre +9 more
TL;DR: It is reported here that culture of the murine lymphoma mutant cell line RMA-S at reduced temperature promotes assembly, and results in a high level of cell surface expression of H-2/β2-microglobulin complexes that do not present endogenous antigens, and are labile at 37 °C.